Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes? (Q53150911)

From Wikidata

Jump to navigation Jump to search

scientific article published on 18 August 2012

Language	Label	Description	Also known as
English	Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?	scientific article published on 18 August 2012

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes? (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

type 2 diabetes

1 reference

based on heuristic

inferred from title

author name string

Z Lehner

1

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

K Stadlbauer

2

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

I Adorjan

3

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

I Rustenbeck

4

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

M Belz

5

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

A Fenzl

6

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

V A M de Cillia

7

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

D Gruber

8

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

L Bauer

9

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

K Frobel

10

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

B Brunmair

11

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

A Luger

12

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

C Fürnsinn

13

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

publication date

18 August 2012

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

55

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

11

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

3071-3082

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

α2-adrenoceptor regulation of blood glucose homeostasis.

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

alpha2A-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues?

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Phentolamine block of K ATP channels is mediated by Kir6.2

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as a ligand

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Selective enhancement of nutrient-induced insulin secretion by ATP-sensitive K channel-blocking imidazolines

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K channels

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet nitric oxide generation in the mouse

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Two generations of insulinotropic imidazoline compounds

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R.

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Phentolamine and yohimbine inhibit ATP-sensitive K channels in mouse pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Cytosolic ADP enhances the sensitivity to tolbutamide of ATP-dependent K channels from pancreatic B-cells

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K channel in mouse pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K channel-blocking compounds

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

alpha2A-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Alpha2-adrenoceptor modulation of cortical acetylcholine release in vivo

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Reduction of hyperglycemia after oral glucose load by the new alpha 2-adrenergic receptor antagonist SL 84.0418 in healthy subjects.

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

The role of I(1)-imidazoline and alpha(2)-adrenergic receptors in the modulation of glucose metabolism in the spontaneously hypertensive obese rat model of metabolic syndrome X.

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Stimulation of insulin secretion by the imidazoline α2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site

1 reference

https://api.crossref.org/works/10.1007/S00125-012-2679-X

21 January 2018

Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acute alpha 2-blockade on insulin action and secretion in humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

More is not always better: alpha2A-adrenoceptor expression in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-adrenoceptor blockade does not enhance glucose-induced insulin release in normal subjects or patients with noninsulin-dependent diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alpha-adrenergic blockade on insulin secretion in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The imidazoline SL 84.0418 shows stereoselectivity in blocking alpha 2-adrenoceptors but not ATP-sensitive K channels in pancreatic B-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initial phase II clinical studies on midaglizole (DG-5128). A new hypoglycemic agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of α2-adrenoceptor subtypes A and C in glucose homeostasis and adrenaline-induced hyperglycaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of midaglizole (DG-5128). A new type of oral hypoglycemic drug in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An insulin-releasing property of imidazoline derivatives is not limited to compounds that block alpha-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha2A-adrenergic receptors and type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22898767

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-012-2679-X

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/22898767

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q53150911&oldid=2212010409"