A structural biology view of target drugability. (Q53116285)

11 May 2018

title

A structural biology view of target drugability. (English)

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11 May 2018

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Ursula Egner

1

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11 May 2018

Roman C Hillig

series ordinal

2

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11 May 2018

language of work or name

English

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publication date

1 April 2008

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11 May 2018

Expert Opinion on Drug Discovery

published in

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11 May 2018

volume

3

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11 May 2018

issue

4

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11 May 2018

page(s)

391-401

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11 May 2018

https://api.crossref.org/works/10.1517/17460441.3.4.391

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Drugs, their targets and the nature and number of drug targets

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

DrugBank: a comprehensive resource for in silico drug discovery and exploration

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Therapeutic targets: progress of their exploration and investigation of their characteristics.

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

How many drug targets are there?

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

TTD: Therapeutic Target Database

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Global mapping of pharmacological space

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

The druggable genome: an update

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Druggability of human disease genes

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Support vector machines approach for predicting druggable proteins: recent progress in its exploration and investigation of its usefulness.

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

A practical view of 'druggability'.

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Progress and problems in the exploration of therapeutic targets

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

The chemical hunt for the identification of drugable targets.

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

The target discovery process

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Predicting protein druggability

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Library design for fragment based screening

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Druggability indices for protein targets derived from NMR-based screening data

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Prediction of protein solvent accessibility using support vector machines.

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

TarFisDock: a web server for identifying drug targets with docking approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Interrogating the druggable genome with structural informatics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Pfam: clans, web tools and services

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Structural interaction fingerprint (SIFt): a novel method for analyzing three-dimensional protein-ligand binding interactions

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

High affinity targets of protein kinase inhibitors have similar residues at the positions energetically important for binding

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

The Protein Data Bank and the challenge of structural genomics

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

21 January 2018

The Protein Data Bank

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Representativity of target families in the Protein Data Bank: impact for family-directed structure-based drug discovery

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Are AM1 ligand-protein binding enthalpies good enough for use in the rational design of new drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Methods for the prediction of protein-ligand binding sites for structure-based drug design and virtual ligand screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

On the nature of cavities on protein surfaces: application to the identification of drug-binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Pocketome via comprehensive identification and classification of ligand binding envelopes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

A method for localizing ligand binding pockets in protein structures

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

sc-PDB: an annotated database of druggable binding sites from the Protein Data Bank

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Identification of the ligand binding sites on the molecular surface of proteins

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Effects of conformational dynamics on predicted protein druggability.

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Structure-based maximal affinity model predicts small-molecule druggability.

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

The evolution of synthetic oral drug properties.

21 January 2018

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https://api.crossref.org/works/10.1517/17460441.3.4.391

Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Plasticity of enzyme active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Kinase inhibition with BAY 43-9006 in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Small molecule protein-protein inhibitors for the p53-MDM2 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Crystal structures of two potent nonamidine inhibitors bound to factor Xa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Macrocyclic aminopyrimidines as multitarget CDK and VEGF-R inhibitors with potent antiproliferative activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

QM/MM calculations with DFT for taking into account protein effects on the EPR and optical spectra of metalloproteins. Plastocyanin as a case study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

Transient Pockets on Protein Surfaces Involved in Protein−Protein Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/17460441.3.4.391

21 January 2018

Identifiers

DOI

10.1517/17460441.3.4.391

1 reference

11 May 2018

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Fatcat ID

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https://api.fatcat.wiki/v0/release/qx6ccms4yrellfsva4ywymz4uu

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11 May 2018