K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice. (Q53101926)

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4 April 2020

title

K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice (English)

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4 April 2020

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Alberto J Schuhmacher

2

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Alba De Martino Rodriguez

4 April 2020

6

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4 April 2020

Carmen Guerra

7

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4 April 2020

author name string

Isabel Hernández-Porras

1

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4 April 2020

Raquel Garcia-Medina

3

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4 April 2020

Beatriz Jiménez

4

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Marta Cañamero

5

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publication date

26 April 2016

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4 April 2020

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volume

239

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issue

2

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page(s)

206-217

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Hyperactive Ras in developmental disorders and cancer

4 April 2020

cites work

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Ras in Cancer and Developmental Diseases

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Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome

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Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis

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Noonan syndrome and clinically related disorders

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Tumor predisposition in Costello syndrome

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RAS diseases in children

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Cancer risk in patients with Noonan syndrome carrying a PTPN11 mutation.

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K-RasV14I recapitulates Noonan syndrome in mice

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

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LKB1 modulates lung cancer differentiation and metastasis

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer

21 January 2018

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A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

21 January 2018

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HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy.

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Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene

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21 January 2018

Identifiers

DOI

10.1002/PATH.4719

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4 April 2020

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