Allosteric modulation as a unifying mechanism for receptor function and regulation. (Q53082766)

11 May 2018

title

Allosteric modulation as a unifying mechanism for receptor function and regulation. (English)

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11 May 2018

1

Jean-Pierre Changeux

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11 May 2018

Arthur Christopoulos

series ordinal

2

object named as

Arthur Christopoulos

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11 May 2018

publication date

1 September 2017

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11 May 2018

Diabetes, Obesity and Metabolism

published in

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11 May 2018

volume

19 Suppl 1

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11 May 2018

page(s)

4-21

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11 May 2018

The feedback control mechanisms of biosynthetic L-threonine deaminase by L-isoleucine

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Dimers and beyond: The functional puzzles of class C GPCRs.

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Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

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Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases.

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Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

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Activation of nuclear receptors: a perspective from structural genomics

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Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

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Multidomain integration in the structure of the HNF-4α nuclear receptor complex

21 January 2018

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Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

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Allosteric mechanisms of signal transduction

21 January 2018

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Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

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Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.

21 January 2018

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A gating mechanism of pentameric ligand-gated ion channels

21 January 2018

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Mapping the conformational wave of acetylcholine receptor channel gating

21 January 2018

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A stepwise mechanism for acetylcholine receptor channel gating

21 January 2018

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X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.

21 January 2018

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One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

21 January 2018

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Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

21 January 2018

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Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

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A locally closed conformation of a bacterial pentameric proton-gated ion channel

21 January 2018

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Intermediate closed state for glycine receptor function revealed by cysteine cross-linking

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The multiple phenotypes of allosteric receptor mutants

21 January 2018

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On the nature of allosteric transitions: implications of non-exclusive ligand binding

21 January 2018

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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

21 January 2018

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Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

21 January 2018

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Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

21 January 2018

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An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway.

21 January 2018

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Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

21 January 2018

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Function and structure of inherently disordered proteins

21 January 2018

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Intrinsically disordered proteins in cellular signalling and regulation.

21 January 2018

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Allosteric coupling via distant disorder-to-order transitions

21 January 2018

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Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

21 January 2018

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Intrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors

21 January 2018

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Intrinsically disordered regions of human plasma membrane proteins preferentially occur in the cytoplasmic segment.

21 January 2018

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Universal allosteric mechanism for Gα activation by GPCRs

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Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

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Minireview: dynamic structures of nuclear hormone receptors: new promises and challenges

21 January 2018

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Structural and functional analysis of domains of the progesterone receptor

21 January 2018

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Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.

21 January 2018

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Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2 -binding sites

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Potentiation of nicotinic receptor response by external calcium in rat central neurons

21 January 2018

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Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

21 January 2018

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Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

21 January 2018

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Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.

21 January 2018

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Deduction of amino acid residues in the GABA(A) receptor alpha subunits photoaffinity labeled with the benzodiazepine flunitrazepam

21 January 2018

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Allosteric modulation of nicotinic acetylcholine receptors

21 January 2018

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X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

21 January 2018

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Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

21 January 2018

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Analysis of γ-aminobutyric acid (GABA) type A receptor subtypes using isosteric and allosteric ligands

21 January 2018

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Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

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Embedded cholesterol in the nicotinic acetylcholine receptor

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A predicted binding site for cholesterol on the GABAA receptor

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Glutamate receptor ion channels: structure, regulation, and function

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Allosteric modulators of NMDA receptors: multiple sites and mechanisms.

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Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

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AMPA receptor potentiators: from drug design to cognitive enhancement

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Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

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Pharmacology, structure and function of cardiac L-type Ca(2 ) channels

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Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

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Advances in G protein-coupled receptor allostery: from function to structure

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Novel Allosteric Modulators of G Protein-coupled Receptors

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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Allosteric targeting of receptor tyrosine kinases.

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Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity

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An alternate binding site for PPARγ ligands

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Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)

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Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators

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Integrin structure, allostery, and bidirectional signaling

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Assembly and localization of Toll-like receptor signalling complexes.

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Integrins: bidirectional, allosteric signaling machines

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Regulation of integrin affinity on cell surfaces

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Drugs from emasculated hormones: the principle of syntopic antagonism

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Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

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A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief

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Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

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Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling

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Rhodopsin dimers in native disc membranes

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Identifiers

DOI

10.1111/DOM.12959

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11 May 2018

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11 May 2018