Costimulatory blockade-induced allograft survival requires Beclin1. (Q53067747)

11 May 2018

title

Costimulatory blockade-induced allograft survival requires Beclin1. (English)

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11 May 2018

author name string

D A Verghese

1

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A Yadav

2

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P Bizargity

3

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B Murphy

4

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P S Heeger

5

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B Schröppel

6

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language of work or name

English

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publication date

6 February 2014

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American Journal of Transplantation

published in

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volume

14

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issue

3

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page(s)

545-553

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Autophagy in immunity and inflammation

cites work

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Regulation mechanisms and signaling pathways of autophagy

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Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

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Macroautophagy regulates energy metabolism during effector T cell activation

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A critical role for the autophagy gene Atg5 in T cell survival and proliferation

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Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34.

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Autophagy is induced in CD4 T cells and important for the growth factor-withdrawal cell death

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Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4.

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Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 January 2018

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Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice

21 January 2018

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Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.

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TGF-beta-induced Foxp3 regulatory T cells rescue scurfy mice

21 January 2018

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T cell death and transplantation tolerance.

21 January 2018

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Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death

21 January 2018

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Autophagy is essential for mitochondrial clearance in mature T lymphocytes

21 January 2018

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Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

21 January 2018

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Self-eating and self-killing: crosstalk between autophagy and apoptosis

21 January 2018

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Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

21 January 2018

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Regulatory T cells in transplantation tolerance

21 January 2018

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Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

21 January 2018

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Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/AJT.12610

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11 May 2018

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11 May 2018