Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. (Q52994249)

10 May 2018

title

Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. (English)

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8

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author name string

Mayuri Shukla

1

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Htut Htut Htoo

2

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Phitchayapak Wintachai

3

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Jean-Francois Hernandez

4

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Claire Dubois

5

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Rolf Postina

6

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Huaxi Xu

7

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Duncan R Smith

9

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Piyarat Govitrapong

10

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Bruno Vincent

11

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publication date

27 December 2014

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Journal of Pineal Research

published in

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volume

58

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issue

2

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page(s)

151-165

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Role of the melatonin system in the control of sleep: therapeutic implications

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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

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Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

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Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients

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Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

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The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway

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Identifiers

DOI

10.1111/JPI.12200

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10 May 2018

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10 May 2018