A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials. (Q52725822)

http://europepmc.org/abstract/PMC/5850906

6 May 2018

title

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials. (English)

1 reference

http://europepmc.org/abstract/PMC/5850906

6 May 2018

author

Cristiano Scottà

7

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7 June 2020

author name string

Henrieta Fraser

1

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7 June 2020

Niloufar Safinia

2

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7 June 2020

Nathali Grageda

3

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7 June 2020

Sarah Thirkell

4

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7 June 2020

Katie Lowe

5

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7 June 2020

Laura J Fry

6

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7 June 2020

Andrew Hope

8

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7 June 2020

Christopher Fisher

9

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7 June 2020

Rachel Hilton

10

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7 June 2020

David Game

11

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7 June 2020

Paul Harden

12

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7 June 2020

Andrew Bushell

13

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7 June 2020

Kathryn Wood

14

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7 June 2020

Robert I Lechler

15

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7 June 2020

Giovanna Lombardi

16

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7 June 2020

publication date

31 January 2018

1 reference

http://europepmc.org/abstract/PMC/5850906

6 May 2018

published in

Molecular Therapy. Methods & Clinical Development

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7 June 2020

volume

8

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7 June 2020

page(s)

198-209

1 reference

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Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34 stem cells-reconstituted NOD-scid IL2rγnull mice

7 June 2020

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection.

22 May 2018

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22 May 2018

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Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

22 May 2018

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Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells

22 May 2018

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Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model.

22 May 2018

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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

22 May 2018

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Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society

22 May 2018

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Developmental plasticity of Foxp3 regulatory T cells

22 May 2018

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In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells

22 May 2018

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mTOR regulates memory CD8 T-cell differentiation

22 May 2018

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

22 May 2018

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Optimization and limitations of use of cryopreserved peripheral blood mononuclear cells for functional and phenotypic T-cell characterization

22 May 2018

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Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy

22 May 2018

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Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin

22 May 2018

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Prevention of acute and chronic allograft rejection with CD4 CD25 Foxp3 regulatory T lymphocytes

22 May 2018

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Differential impact of mammalian target of rapamycin inhibition on CD4 CD25 Foxp3 regulatory T cells compared with conventional CD4 T cells

22 May 2018

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22 May 2018

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22 May 2018

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Supplementation of Conventional Freezing Medium with a Combination of Catalase and Trehalose Results in Better Protection of Surface Molecules and Functionality of Hematopoietic Cells

22 May 2018

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22 May 2018

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CD39 Foxp3 regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5850906

Indefinite mouse heart allograft survival in recipient treated with CD4( )CD25( ) regulatory T cells with indirect allospecificity and short term immunosuppression.

13 August 2018

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13 August 2018

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Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

13 August 2018

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Effective treatment of collagen-induced arthritis by adoptive transfer of CD25 regulatory T cells.

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5850906

CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5850906

Rapamycin selectively expands CD4 CD25 FoxP3 regulatory T cells.

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5850906

L-Selectin(hi) but not the L-selectin(lo) CD4 25 T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5850906

CD4 and CD8 cells in cryopreserved human PBMC maintain full functionality in cytokine ELISPOT assays

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5850906

Selective survival of naturally occurring human CD4 CD25 Foxp3 regulatory T cells cultured with rapamycin

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5850906

CD4( )CD25( ) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid

2 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5850906

The infusion of ex vivo activated and expanded CD4( )CD25( ) immune regulatory cells inhibits graft-versus-host disease lethality

2 November 2018

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12 December 2020

Cutting edge: CD4 CD25 regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis

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12 December 2020

In vitro-expanded donor alloantigen-specific CD4 CD25 regulatory T cells promote experimental transplantation tolerance

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12 December 2020

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4 CD25 CD127- T regulatory cells

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12 December 2020

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

1 reference

12 December 2020

Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls

1 reference

12 December 2020

Therapy of type 1 diabetes with CD4( )CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up

1 reference

12 December 2020

10.1016/J.OMTM.2018.01.006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29552576 AND SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29552576 AND SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

29552576

1 reference