Discovery of a glucocorticoid receptor (GR) activity signature using selective GR antagonism in ER-negative breast cancer. (Q52720231)

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22 March 2020

title

Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer (English)

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16

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17

Judy C Boughey

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18

Matthew P Goetz

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7

Jason P Sinnwell

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8

Kevin J Thompson

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19

Krishna R Kalari

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20

Liewei Wang

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author name string

Masha Kocherginsky

2

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Eva Y Tonsing-Carter

3

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David J Hosfield

5

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Ricardo R Lastra

6

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Kathleen R Bowie

9

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Ryan V Harkless

10

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Maxwell N Skor

11

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Charles F Pierce

12

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Sarah C Styke

13

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Caroline R Kim

14

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Larischa de Wet

15

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Gini F Fleming

21

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Suzanne D Conzen

23

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Diana C West

1

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D Nesli Dolcen

4

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Balázs Györffy

22

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language of work or name

English

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publication date

10 April 2018

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22 March 2020

published in

Clinical Cancer Research

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volume

24

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issue

14

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22 March 2020

page(s)

3433-3446

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Dexamethasone induces partial resistance to cisplatinum in C6 glioma cells.

22 March 2020

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The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells

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Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells

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Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction

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Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer

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Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling

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Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.

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Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor

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A meta-analysis of gene expression-based biomarkers predicting outcome after tamoxifen treatment in breast cancer

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Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer

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Tackling the diversity of triple-negative breast cancer

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Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade

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Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets

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Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner

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Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer

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Cofactor profiling of the glucocorticoid receptor from a cellular environment

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Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo

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12 December 2020

Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer

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Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma

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Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer

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12 December 2020

Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

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Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer

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12 December 2020

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

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Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer

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Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer

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GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER Breast Cancer Outcome

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Genome-wide DNA methylation profiling in triple-negative breast cancer reveals epigenetic signatures with important clinical value

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Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection.

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Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

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Dexamethasone induces docetaxel and cisplatin resistance partially through up-regulating Krüppel-like factor 5 in triple-negative breast cancer

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Glucocorticoid receptor signalling activates YAP in breast cancer

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12 December 2020

Long-Term Prognostic Risk After Neoadjuvant Chemotherapy Associated With Residual Cancer Burden and Breast Cancer Subtype

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12 December 2020

Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Re

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Tumor Sequencing and Patient-Derived Xenografts in the Neoadjuvant Treatment of Breast Cancer

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Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth.

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Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program.

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Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

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10.1158/1078-0432.CCR-17-2793

Identifiers

DOI

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22 March 2020

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22 March 2020

PubMed publication ID

29636357

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