Matricellular CCN6 (WISP3) protein: a tumor suppressor for mammary metaplastic carcinomas. (Q52709107)

6 May 2018

title

Matricellular CCN6 (WISP3) protein: a tumor suppressor for mammary metaplastic carcinomas. (English)

1 reference

6 May 2018

author name string

Mai N Tran

series ordinal

1

1 reference

6 May 2018

Celina G Kleer

series ordinal

2

1 reference

6 May 2018

publication date

22 January 2018

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6 May 2018

Journal of Cell Communication and Signaling

published in

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6 May 2018

volume

12

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6 May 2018

issue

1

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6 May 2018

page(s)

13-19

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6 May 2018

MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas

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Abnormal Mammary Adipose Tissue Environment of Brca1 Mutant Mice Show a Persistent Deposition of Highly Vascularized Multilocular Adipocytes.

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Unique clinicopathological features of metaplastic breast carcinoma compared with invasive ductal carcinoma and poor prognostic indicators

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CCN6 knockdown disrupts acinar organization of breast cells in three-dimensional cultures through up-regulation of type III TGF-β receptor

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CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer

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CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer

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Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells

22 May 2018

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22 May 2018

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Normal growth and development in mice over-expressing the CCN family member WISP3

22 May 2018

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22 May 2018

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22 May 2018

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Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.

22 May 2018

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22 May 2018

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22 May 2018

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The CCN3 protein and cancer

22 May 2018

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BRCA1 dysfunction in sporadic basal-like breast cancer

22 May 2018

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22 May 2018

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22 May 2018

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Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells

22 May 2018

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Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation

22 May 2018

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WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice

22 May 2018

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22 May 2018

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WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer

22 May 2018

1 reference

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CCN proteins: multifunctional signalling regulators

22 May 2018

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WISP3 is a novel tumor suppressor gene of inflammatory breast cancer

22 May 2018

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NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues

22 May 2018

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Role of transforming growth factor-beta signaling in cancer

22 May 2018

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22 May 2018

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Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions

22 May 2018

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A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.

22 May 2018

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Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia.

22 May 2018

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22 May 2018

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Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

Loss of heterozygosity at chromosome 6q in preinvasive and early invasive breast carcinomas

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

The modular architecture of a new family of growth regulators related to connective tissue growth factor

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

Classification of metaplastic carcinomas of the breast

22 May 2018

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The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas.

22 May 2018

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Report on the second international workshop on the CCN family of genes

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

Localization of the IGF binding domain and evaluation of the role of cysteine residues in IGF binding in IGF binding protein-4.

13 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5842205

Detection of frequent allelic loss of 6q23-q25.2 in microdissected human breast cancer tissues

13 August 2018

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12 December 2020

At least five regions of imbalance on 6q in breast tumors, combining losses and gains

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12 December 2020

p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma

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12 December 2020

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12 December 2020

10.1007/S12079-018-0451-9

Identifiers

DOI

1 reference

6 May 2018

release_c53pk76fufh43pwxtdi2tljmsi

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/c53pk76fufh43pwxtdi2tljmsi

24 November 2022

mapped directly with Wikidata item

PMC publication ID

5842205

1 reference

6 May 2018

PubMed publication ID

29357008

1 reference

6 May 2018