Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents. (Q52688576)

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18 March 2020

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13 September 2020

Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents (English)

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Zhi-Shu Huang

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Yu-Qing Wang

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Zhou-Li Huang

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Jia-Heng Tan

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Shuo-Bin Chen

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English

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23 February 2018

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13 September 2020

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Creative Commons Attribution

18 March 2020

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13 September 2020

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Constituents of West African Medicinal Plants XX: Quindoline from Cryptolepis sanguinolenta

1 reference

12 December 2020

Quadruplex structure of Oxytricha telomeric DNA oligonucleotides

1 reference

12 December 2020

Structure and function of telomeres

1 reference

12 December 2020

Telomerase activity associated with acquisition of malignancy in human colorectal cancer.

1 reference

12 December 2020

FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis.

1 reference

12 December 2020

The Hallmarks of Cancer

1 reference

12 December 2020

A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline

1 reference

12 December 2020

In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

1 reference

12 December 2020

Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus

1 reference

12 December 2020

Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

1 reference

12 December 2020

Crystal structure of parallel quadruplexes from human telomeric DNA

1 reference

12 December 2020

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

1 reference

12 December 2020

Intramolecular Higher Order Packing of Parallel Quadruplexes Comprising a G:G:G:G Tetrad and a G(:A):G(:A):G(:A):G Heptad of GGA Triplet Repeat DNA

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12 December 2020

Helix formation by guanylic acid

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12 December 2020

Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.

1 reference

12 December 2020

Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.

1 reference

12 December 2020

Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter

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12 December 2020

Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative

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12 December 2020

Prevalence of quadruplexes in the human genome

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12 December 2020

Preferential binding of a G-quadruplex ligand to human chromosome ends.

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12 December 2020

Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines

1 reference

12 December 2020

Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents

1 reference

12 December 2020

Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase

1 reference

12 December 2020

Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter

1 reference

12 December 2020

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation

1 reference

12 December 2020

An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution

1 reference

12 December 2020

Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)

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12 December 2020

Verification of antiparallel G-quadruplex structure in human telomeres by using two-photon excitation fluorescence lifetime imaging microscopy of the 3,6-Bis(1-methyl-4-vinylpyridinium)carbazole diiodide molecule

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12 December 2020

Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex

1 reference

12 December 2020

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

1 reference

12 December 2020

Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution

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12 December 2020

Development of a fluorescent intercalator displacement assay (G4-FID) for establishing quadruplex-DNA affinity and selectivity of putative ligands

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12 December 2020

Gene function correlates with potential for G4 DNA formation in the human genome

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12 December 2020

Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives

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12 December 2020

Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter

1 reference

12 December 2020

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

1 reference

12 December 2020

9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA.

1 reference

12 December 2020

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K solution: insights into structure polymorphism of the human telomeric sequence

1 reference

12 December 2020

Surface plasmon resonance for probing quadruplex folding and interactions with proteins and small molecules

1 reference

12 December 2020

Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4

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12 December 2020

G-quadruplexes: targets in anticancer drug design.

1 reference

12 December 2020

9-N-Substituted berberine derivatives: stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc

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12 December 2020

Modelling Myc inhibition as a cancer therapy

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12 December 2020

5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.

1 reference

12 December 2020

Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods

1 reference

12 December 2020

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

1 reference

12 December 2020

Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA.

1 reference

12 December 2020

Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands

1 reference

12 December 2020

The structures of quadruplex nucleic acids and their drug complexes

1 reference

12 December 2020

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis

1 reference

12 December 2020

Tandem Application of Virtual Screening and NMR Experiments in the Discovery of Brand New DNA Quadruplex Groove Binders

1 reference

12 December 2020

Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand

1 reference

12 December 2020

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

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12 December 2020

Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex

1 reference

12 December 2020

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

1 reference

12 December 2020

Impact of planarity of unfused aromatic molecules on G-quadruplex binding: learning from isaindigotone derivatives.

1 reference

12 December 2020

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

1 reference

12 December 2020

Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.

1 reference

12 December 2020

Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands

1 reference

12 December 2020

Small-molecule-induced DNA damage identifies alternative DNA structures in human genes

1 reference

12 December 2020

Interaction of Berberine derivative with protein POT1 affect telomere function in cancer cells

1 reference

12 December 2020

G-quadruplex binding ligands: from naturally occurring to rationally designed molecules

1 reference

12 December 2020

A FRET-based screening assay for nucleic acid ligands.

1 reference

12 December 2020

12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: a new class of highly selective ligands for c-myc G-quadruplex DNA.

1 reference

12 December 2020

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

1 reference

12 December 2020

Benzofuroquinoline derivatives had remarkable improvement of their selectivity for telomeric G-quadruplex DNA over duplex DNA upon introduction of peptidyl group

1 reference

12 December 2020

Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes.

1 reference

12 December 2020

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

1 reference

12 December 2020

Quantitative visualization of DNA G-quadruplex structures in human cells

1 reference

12 December 2020

Fluorescent probes for G-quadruplex structures.

1 reference

12 December 2020

New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.

1 reference

12 December 2020

Solution structure of an intramolecular (3 1) human telomeric G-quadruplex bound to a telomestatin derivative

1 reference

12 December 2020

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

1 reference

12 December 2020

Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3)

1 reference

12 December 2020

Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids.

1 reference

12 December 2020

Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands.

1 reference

12 December 2020

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

1 reference

12 December 2020

G-quadruplex interacting small molecules and drugs: from bench toward bedside

1 reference

12 December 2020

A twice-as-smart synthetic G-quartet: PyroTASQ is both a smart quadruplex ligand and a smart fluorescent probe

1 reference

12 December 2020

Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes

1 reference

12 December 2020

Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations.

1 reference

12 December 2020

Recent Development of G-Quadruplex Probes for Cellular Imaging.

1 reference

12 December 2020

Biological Function of G-Quadruplex Nucleic Acids and Potential Application in Medicinal Chemistry

1 reference

12 December 2020

Development of a highly sensitive fluorescent light-up probe for G-quadruplexes

1 reference

12 December 2020

Visualization of RNA-Quadruplexes in Live Cells

1 reference

12 December 2020

Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule

1 reference

12 December 2020

High-throughput sequencing of DNA G-quadruplex structures in the human genome

1 reference

12 December 2020

A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region

1 reference

12 December 2020

A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology

1 reference

12 December 2020

Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole

1 reference

12 December 2020

Design, synthesis and biological evaluation of 4-anilinoquinazoline derivatives as new c-myc G-quadruplex ligands

1 reference

12 December 2020

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

1 reference

12 December 2020

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome

1 reference

12 December 2020

G-quadruplex structures mark human regulatory chromatin

1 reference

12 December 2020

RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria

1 reference

12 December 2020

Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole

1 reference

12 December 2020

Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex.

1 reference

12 December 2020

Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.

1 reference

12 December 2020

G-quadruplex-forming promoter sequences enable transcriptional activation in response to oxidative stress.

1 reference

12 December 2020

Synthesis and evaluation of 7-substituted-5,6-dihydrobenzo[c]acridine derivatives as new c-KIT promoter G-quadruplex binding ligands.

1 reference

12 December 2020

Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units.

1 reference

12 December 2020

Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.

1 reference

12 December 2020

An Aggregating Amphiphilic Squaraine: A Light-up Probe That Discriminates Parallel G-Quadruplexes

1 reference

12 December 2020

Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents.

1 reference

12 December 2020

New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.

1 reference

12 December 2020

Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction

1 reference

12 December 2020

10.3390/MOLECULES23020493

Identifiers

DOI

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18 March 2020

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18 March 2020

PubMed publication ID

29473874

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