Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency. (Q52641721)

5 May 2018

title

Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency. (English)

1 reference

5 May 2018

author

Klaus-Michael Debatin

13

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5 May 2018

Jan-Bernd Funcke

object named as

Jan-Bernd Funcke

3

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Martin Wabitsch

15

object named as

Martin Wabitsch

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5 May 2018

Katja Kohlsdorf

1

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5 May 2018

Adriana Nunziata

2

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5 May 2018

Stephanie Brandt

4

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5 May 2018

Julia von Schnurbein

5

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5 May 2018

Heike Vollbach

6

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5 May 2018

Belinda Lennerz

7

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5 May 2018

Maria Fritsch

8

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5 May 2018

Susanne Greber-Platzer

9

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5 May 2018

Elke Fröhlich-Reiterer

10

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5 May 2018

Manuel Luedeke

11

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5 May 2018

Guntram Borck

12

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5 May 2018

Pamela Fischer-Posovszky

14

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5 May 2018

language of work or name

English

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publication date

27 February 2018

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5 May 2018

International Journal of Obesity

published in

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5 May 2018

Positional cloning of the mouse obese gene and its human homologue

cites work

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohort

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

The hunger genes: pathways to obesity

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

20 years of leptin: human disorders of leptin action

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Monogenic forms of childhood obesity due to mutations in the leptin gene

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Biologically inactive leptin and early-onset extreme obesity

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

The stigma of obesity: a review and update

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Perceptions of weight discrimination: prevalence and comparison to race and gender discrimination in America

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

[Monogenic and syndromic symptoms of morbid obesity. Rare but important].

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Homozygous null mutation of the melanocortin-4 receptor and severe early-onset obesity

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Seven novel deleterious LEPR mutations found in early-onset obesity: a ΔExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Perzentile für den Body-mass-Index für das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher Stichproben

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Response to Letter: "Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline".

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Leptin substitution results in the induction of menstrual cycles in an adolescent with leptin deficiency and hypogonadotropic hypogonadism.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

New percentile values for the anthropometric dimensions of singleton neonates: analysis of perinatal survey data of 2007-2011 from all 16 states of Germany

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

The Limitations of Transforming Very High Body Mass Indexes into z-Scores among 8.7 Million 2- to 4-Year-Old Children

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

BMI z-Scores are a poor indicator of adiposity among 2- to 19-year-olds with very high BMIs, NHANES 1999-2000 to 2013-2014.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

A leptin missense mutation associated with hypogonadism and morbid obesity.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

The p. N103K mutation of leptin (LEP) gene and severe early onset obesity in Pakistan

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Prevalence of Mutations and Functional Analyses of Melanocortin 4 Receptor Variants Identified among 750 Men with Juvenile-Onset Obesity

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Melanocortin-4 receptor polymorphisms in Turkish pediatric obese patients

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults

1 reference

https://api.crossref.org/works/10.1038/S41366-018-0049-6

7 January 2021

10.1038/S41366-018-0049-6

Identifiers

DOI

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5 May 2018

1 reference

5 May 2018