Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. (Q52536019)

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11 December 2019

title

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2 (English)

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11 December 2019

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4

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11 December 2019

Hyunsook Lee

1

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11 December 2019

author name string

A H Trainer

2

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11 December 2019

L S Friedman

3

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11 December 2019

M J Evans

5

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11 December 2019

B A Ponder

6

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11 December 2019

A R Venkitaraman

7

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11 December 2019

publication date

1 July 1999

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11 December 2019

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11 December 2019

volume

4

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11 December 2019

issue

1

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11 December 2019

page(s)

1-10

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Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

11 December 2019

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Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

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S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

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Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

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The BRCA2 gene product functionally interacts with p53 and RAD51

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Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

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Tumor suppressor p53: analysis of wild-type and mutant p53 complexes

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

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Involvement of Brca2 in DNA repair

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The spindle assembly checkpoint

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RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

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