HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice (Q51986948)

19 April 2018

title

HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice (English)

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19 April 2018

5

Paul Jolicoeur

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19 April 2018

author name string

Zaher Hanna

1

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19 April 2018

Elena Priceputu

2

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19 April 2018

Chunyan Hu

3

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19 April 2018

Patrick Vincent

4

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19 April 2018

language of work or name

English

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publication date

28 November 2005

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19 April 2018

published in

Virology

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19 April 2018

volume

346

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19 April 2018

issue

1

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19 April 2018

page(s)

40-52

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19 April 2018

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

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7 January 2021

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Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

7 January 2021

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Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo

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Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis

7 January 2021

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Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

7 January 2021

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Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes

7 January 2021

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Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication

7 January 2021

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7 January 2021

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Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens

7 January 2021

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7 January 2021

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The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleuk

7 January 2021

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Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein

7 January 2021

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Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

7 January 2021

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HIV and SIV Nef modulate signal transduction and protein sorting in T cells

7 January 2021

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Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis

7 January 2021

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Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression

7 January 2021

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Downregulation of CD4 is required for maintenance of viral infectivity of HIV-1

7 January 2021

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Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors

7 January 2021

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In vivo analysis of Nef function

7 January 2021

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CD4 T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIROL.2005.10.010

Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIROL.2005.10.010

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIROL.2005.10.010

Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIROL.2005.10.010

7 January 2021

Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 in Immune Cells Develop a Severe AIDS-Like Disease

1 reference

https://api.crossref.org/works/10.1016/J.VIROL.2005.10.010

7 January 2021

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

1 reference

https://api.crossref.org/works/10.1016/J.VIROL.2005.10.010

7 January 2021

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

1 reference

https://api.crossref.org/works/10.1016/J.VIROL.2005.10.010

7 January 2021

10.1016/J.VIROL.2005.10.010

Identifiers

DOI

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19 April 2018

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19 April 2018