HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions (Q51974350)

19 April 2018

title

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions (English)

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19 April 2018

main subject

hepatocellular carcinoma

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Juxing Chen

1

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19 April 2018

Maja Chloupková

2

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19 April 2018

Junwei Gao

3

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19 April 2018

Tara L Chapman-Arvedson

4

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19 April 2018

Caroline A Enns

5

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19 April 2018

language of work or name

English

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publication date

23 October 2007

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19 April 2018

Journal of Biological Chemistry

published in

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19 April 2018

volume

282

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19 April 2018

issue

51

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19 April 2018

page(s)

36862-36870

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19 April 2018

Genetics of hemochromatosis

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Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

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21 January 2018

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Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

21 January 2018

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The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

21 January 2018

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Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation

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The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells

21 January 2018

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Localization of iron metabolism–related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

21 January 2018

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Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

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Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo

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Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE

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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

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The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

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The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18.

21 January 2018

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Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor.

21 January 2018

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Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments

21 January 2018

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21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Identification of critical IgG binding epitopes on the neonatal Fc receptor

21 January 2018

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The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor

21 January 2018

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Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites

21 January 2018

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Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M706720200

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19 April 2018

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19 April 2018