CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis. (Q51322003)

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27 March 2020

title

CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis (English)

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27 March 2020

5

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27 March 2020

Johannes Zuber

10

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27 March 2020

Lukas Kenner

12

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27 March 2020

Gregor Hoermann

16

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27 March 2020

Georg Greiner

1

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27 March 2020

Peter Valent

14

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27 March 2020

author name string

Nadine Witzeneder

2

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27 March 2020

Angelika Berger

3

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27 March 2020

Klaus Schmetterer

4

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27 March 2020

Ana-Iris Schiefer

6

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27 March 2020

Simone Roos

7

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27 March 2020

Theresia Popow-Kraupp

8

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27 March 2020

Leonhard Müllauer

9

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27 March 2020

Veronika Sexl

11

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27 March 2020

Wolfgang R Sperr

13

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27 March 2020

Matthias Mayerhofer

15

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27 March 2020

language of work or name

English

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publication date

16 November 2016

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27 March 2020

number of pages

12

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inferred from page(s)

published in

Blood

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27 March 2020

volume

129

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27 March 2020

issue

3

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27 March 2020

page(s)

371-382

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Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade

27 March 2020

cites work

1 reference

12 December 2020

Diagnostic criteria and classification of mastocytosis: a consensus proposal

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12 December 2020

CD52 is a molecular target in advanced systemic mastocytosis.

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12 December 2020

Expression of multiple chemokine genes by a human mast cell leukemia

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Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes.

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Serum IL-31 levels are increased in a subset of patients with mastocytosis and correlate with disease severity in adult patients

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STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells.

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12 December 2020

Comprehensive mutational profiling in advanced systemic mastocytosis

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12 December 2020

An immature immunophenotype of bone marrow mast cells predicts for multilineage D816V KIT mutation in systemic mastocytosis.

1 reference

12 December 2020

A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors

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12 December 2020

Midostaurin in Advanced Systemic Mastocytosis

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12 December 2020

Serum levels of bone cytokines are increased in indolent systemic mastocytosis associated with osteopenia or osteoporosis.

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12 December 2020

Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria

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12 December 2020

Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program.

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12 December 2020

Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase

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12 December 2020

Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression

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12 December 2020

The chemokine CCL2 increases prostate tumor growth and bone metastasis through macrophage and osteoclast recruitment

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Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study

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Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis

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Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients

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Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

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Novel insights into the biology and treatment of chronic myeloproliferative neoplasms

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The MCP/eotaxin subfamily of CC chemokines

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Plasma cytokines in polycythemia vera: phenotypic correlates, prognostic relevance, and comparison with myelofibrosis

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12 December 2020

Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings.

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Angiogenesis in myeloproliferative neoplasms, new markers and future directions.

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Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

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An optimized microRNA backbone for effective single-copy RNAi

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12 December 2020

Cytokine Regulation of Microenvironmental Cells in Myeloproliferative Neoplasms

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12 December 2020

Identification of oncostatin M as a STAT5-dependent mediator of bone marrow remodeling in KIT D816V-positive systemic mastocytosis

1 reference

12 December 2020

IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis

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12 December 2020

Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.

1 reference

12 December 2020

Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic

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Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

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12 December 2020

NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.

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12 December 2020

European consensus on grading bone marrow fibrosis and assessment of cellularity

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12 December 2020

The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism

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12 December 2020

The KIT D816V allele burden predicts survival in patients with mastocytosis and correlates with the WHO type of the disease

1 reference

12 December 2020

Immunohistochemical detection of vascular endothelial growth factor (VEGF) in the bone marrow in patients with myelodysplastic syndromes: correlation between VEGF expression and the FAB category

1 reference

12 December 2020

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

1 reference

12 December 2020

Cytokine profiles in polycythemia vera and essential thrombocythemia patients: clinical implications.

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12 December 2020

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection

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12 December 2020

Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal

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12 December 2020

A protocol for isolation and culture of human umbilical vein endothelial cells.

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12 December 2020

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

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12 December 2020

The c-kit ligand stem cell factor and anti-IgE promote expression of monocyte chemoattractant protein-1 in human lung mast cells

1 reference

12 December 2020

Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo

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12 December 2020

Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis

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12 December 2020

Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation

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12 December 2020

Monocyte chemoattractant protein-1 (MCP-1): an overview

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12 December 2020

The role of cytokines in the initiation and progression of myelofibrosis.

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12 December 2020

Identification of oncostatin M as a JAK2 V617F-dependent amplifier of cytokine production and bone marrow remodeling in myeloproliferative neoplasms

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12 December 2020

Establishment of an immature mast cell line from a patient with mast cell leukemia

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12 December 2020

Circulating levels of MCP‐1, sIL‐2R, IL‐15, and IL‐8 predict anemia response to pomalidomide therapy in myelofibrosis

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12 December 2020

Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line

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12 December 2020

Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells.

1 reference

12 December 2020

Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives.

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12 December 2020

CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer.

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NIH Image to ImageJ: 25 years of image analysis

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12 December 2020

Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB/Rel subunit specificity.

1 reference

12 December 2020

Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression

1 reference

12 December 2020

One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes

1 reference

12 December 2020

10.1182/BLOOD-2016-09-739003

Identifiers

DOI

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27 March 2020

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