SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines. (Q51254236)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27986909 AND SRC:MED&resulttype=core&format=json

30 March 2020

title

SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines (English)

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30 March 2020

3

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30 March 2020

author name string

Lara Toffali

1

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30 March 2020

Alessio Montresor

2

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30 March 2020

Giorgio Scita

4

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30 March 2020

Carlo Laudanna

5

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30 March 2020

language of work or name

English

0 references

publication date

16 December 2016

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27986909 AND SRC:MED&resulttype=core&format=json

30 March 2020

published in

Journal of Immunology

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30 March 2020

volume

198

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30 March 2020

issue

2

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30 March 2020

page(s)

708-717

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30 March 2020

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.1600933

RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing

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The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.

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Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module.

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Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners

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Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking

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JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation

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GEFs and GAPs: critical elements in the control of small G proteins

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

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Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

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Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

21 January 2018

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Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

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DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1.

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The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.

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Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function

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AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.

21 January 2018

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Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell

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Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow

21 January 2018

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Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules

21 January 2018

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Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions

21 January 2018

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Chemokines and the signaling modules regulating integrin affinity

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Rho family GTPases and their regulators in lymphocytes.

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Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

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Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

21 January 2018

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Imaging the Rex vein preoperatively using wedged hepatic venous portography.

21 January 2018

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The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity

21 January 2018

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A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

21 January 2018

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Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

21 January 2018

1 reference

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

21 January 2018

1 reference

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Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion

21 January 2018

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Concurrency in leukocyte vascular recognition: developing the tools for a predictive computer model

21 January 2018

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Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.

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Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.

21 January 2018

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21 January 2018

Identifiers

DOI

10.4049/JIMMUNOL.1600933

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27986909 AND SRC:MED&resulttype=core&format=json

30 March 2020

1 reference