Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer (Q51140192)

30 March 2018

http://europepmc.org/abstract/MED/28191894

title

Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer (English)

1 reference

30 March 2018

http://europepmc.org/abstract/MED/28191894

author

Yuanliang Zhai

1

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11 June 2020

Ning Gao

6

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11 June 2020

Ningning Li

4

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11 June 2020

author name string

Erchao Cheng

2

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11 June 2020

Hao Wu

3

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11 June 2020

Philip Yuk Kwong Yung

5

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11 June 2020

Bik-Kwoon Tye

7

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11 June 2020

publication date

13 February 2017

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30 March 2018

http://europepmc.org/abstract/MED/28191894

published in

Nature Structural & Molecular Biology

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11 June 2020

volume

24

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issue

3

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11 June 2020

page(s)

300-308

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DNA replication and genomic instability

11 June 2020

cites work

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21 January 2018

1 reference

Chromosome Duplication in Saccharomyces cerevisiae.

21 January 2018

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Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase.

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MCM proteins in DNA replication

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The Mcm complex: unwinding the mechanism of a replicative helicase.

21 January 2018

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The minichromosome maintenance replicative helicase

21 January 2018

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Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

21 January 2018

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A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

21 January 2018

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Mechanisms for initiating cellular DNA replication

21 January 2018

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ATPase-dependent quality control of DNA replication origin licensing

21 January 2018

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An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

21 January 2018

1 reference

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

21 January 2018

1 reference

Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading

21 January 2018

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Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function

21 January 2018

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Structure of the eukaryotic MCM complex at 3.8 Å

21 January 2018

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Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.

21 January 2018

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Regulated eukaryotic DNA replication origin firing with purified proteins

21 January 2018

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How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

21 January 2018

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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression

21 January 2018

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Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation

21 January 2018

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Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation

21 January 2018

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Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing

21 January 2018

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Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

21 January 2018

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CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

21 January 2018

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Helicase activation and establishment of replication forks at chromosomal origins of replication.

21 January 2018

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CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast

21 January 2018

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Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.

21 January 2018

1 reference

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA

21 January 2018

1 reference

Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases

21 January 2018

1 reference

Helicase loading: how to build a MCM2-7 double-hexamer.

21 January 2018

1 reference

Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase

21 January 2018

1 reference

Multiple functions for Mcm2-7 ATPase motifs during replication initiation

21 January 2018

1 reference

Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2-7 Helicase to Reveal Essential Features of Structure and Function

21 January 2018

1 reference

A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase

21 January 2018

1 reference

MCM structure and mechanics: what we have learned from archaeal MCM.

21 January 2018

1 reference

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

21 January 2018

1 reference

The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

21 January 2018

1 reference

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation

21 January 2018

1 reference

CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6

21 January 2018

1 reference

Structural insights into the Cdt1-mediated MCM2-7 chromatin loading.

21 January 2018

1 reference

Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors

21 January 2018

1 reference

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

21 January 2018

1 reference

The Mcm2-7 complex has in vitro helicase activity.

21 January 2018

1 reference

A conserved MCM single-stranded DNA binding element is essential for replication initiation

21 January 2018

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On helicases and other motor proteins

21 January 2018

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The nuts and bolts of ring-translocase structure and mechanism

21 January 2018

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Loading strategies of ring-shaped nucleic acid translocases and helicases

21 January 2018

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The bacterial DnaC helicase loader is a DnaB ring breaker

21 January 2018

1 reference

Mechanism of Archaeal MCM Helicase Recruitment to DNA Replication Origins

21 January 2018

1 reference

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex

21 January 2018

1 reference

The RFC clamp loader: structure and function

21 January 2018

1 reference

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

21 January 2018

1 reference

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading

21 January 2018

1 reference

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication

21 January 2018

1 reference

Single-molecule fluorescence reveals the unwinding stepping mechanism of replicative helicase.

21 January 2018

1 reference

The hexameric helicase DnaB adopts a nonplanar conformation during translocation.

21 January 2018

1 reference

Mechanistic insights into the recycling machine of the SNARE complex

21 January 2018

1 reference

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.

21 January 2018

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SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs

21 January 2018

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RELION: implementation of a Bayesian approach to cryo-EM structure determination

21 January 2018

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Accurate determination of local defocus and specimen tilt in electron microscopy

21 January 2018

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UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

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Scalable web services for the PSIPRED Protein Analysis Workbench.

21 January 2018

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The I-TASSER Suite: protein structure and function prediction.

21 January 2018

1 reference

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin

21 January 2018

1 reference

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

21 January 2018

1 reference

Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins

21 January 2018

1 reference

Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex

21 January 2018

1 reference

Towards automated crystallographic structure refinement with phenix.refine

21 January 2018

1 reference

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex

21 January 2018

1 reference

Analysis of the crystal structure of an active MCM hexamer

31 March 2020

1 reference

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.3374

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28191894 AND SRC:MED&resulttype=core&format=json

11 June 2020

1 reference