Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate (Q50777703)

19 March 2018

title

Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate (English)

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19 March 2018

author name string

Sawako Muroi

1

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19 March 2018

Yoshinori Naoe

2

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19 March 2018

Chizuko Miyamoto

3

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19 March 2018

Kaori Akiyama

4

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19 March 2018

Tomokatsu Ikawa

5

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19 March 2018

Kyoko Masuda

6

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19 March 2018

Hiroshi Kawamoto

7

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19 March 2018

Ichiro Taniuchi

8

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19 March 2018

language of work or name

English

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publication date

7 September 2008

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19 March 2018

published in

Nature Immunology

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19 March 2018

volume

9

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19 March 2018

issue

10

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19 March 2018

page(s)

1113-1121

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19 March 2018

Lineage plasticity and commitment in T-cell development

cites work

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Contingent gene regulatory networks and B cell fate specification

21 January 2018

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Determinants of lymphoid-myeloid lineage diversification

21 January 2018

1 reference

The regulation of CD4 and CD8 coreceptor gene expression during T cell development

21 January 2018

1 reference

Asymmetric signaling requirements for thymocyte commitment to the CD4 versus CD8 T cell lineages: a new perspective on thymic commitment and selection

21 January 2018

1 reference

Intermediate steps in positive selection: differentiation of CD4 8int TCRint thymocytes into CD4-8 TCRhi thymocytes

21 January 2018

1 reference

Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4 8lo transitional cells during positive selection of CD8 T cells

21 January 2018

1 reference

Visualization of CD4/CD8 T cell commitment

21 January 2018

1 reference

The duration of antigen receptor signalling determines CD4 versus CD8 T-cell lineage fate

21 January 2018

1 reference

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.

21 January 2018

1 reference

Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

21 January 2018

1 reference

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

21 January 2018

1 reference

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

21 January 2018

1 reference

The role of BTB domain-containing zinc finger proteins in T cell development and function

21 January 2018

1 reference

HD mice: a novel mouse mutant with a specific defect in the generation of CD4( ) T cells

21 January 2018

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Regulation of lineage commitment distinct from positive selection

21 January 2018

1 reference

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

21 January 2018

1 reference

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

21 January 2018

1 reference

CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus

21 January 2018

1 reference

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

1 reference

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

21 January 2018

1 reference

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8 T cells.

21 January 2018

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Depletion of CD4 T cells in major histocompatibility complex class II-deficient mice.

21 January 2018

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T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver

21 January 2018

1 reference

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells.

21 January 2018

1 reference

Control of Effector CD8 T Cell Function by the Transcription Factor Eomesodermin

21 January 2018

1 reference

Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.

21 January 2018

1 reference

Role of the transcription factor Th-POK in CD4:CD8 lineage commitment

21 January 2018

1 reference

RANK signals from CD4( )3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

21 January 2018

1 reference

Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR

21 January 2018

1 reference

The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer

21 January 2018

1 reference

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

21 January 2018

1 reference

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer

21 January 2018

1 reference

Effector and memory CD8 T cell fate coupled by T-bet and eomesodermin

21 January 2018

1 reference

Coreceptor reversal in the thymus: signaled CD4 8 thymocytes initially terminate CD8 transcription even when differentiating into CD8 T cells

21 January 2018

1 reference

7 January 2021

CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

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7 January 2021

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

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7 January 2021

A transcriptional silencer controls the developmental expression of the CD4 gene.

1 reference

7 January 2021

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

1 reference

7 January 2021

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

1 reference

7 January 2021

Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NI.1650

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19 March 2018

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19 March 2018