Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway (Q50754258)

18 March 2018

title

Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway (English)

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18 March 2018

author name string

Kenneth Rogulski

1

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18 March 2018

Youjun Li

2

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18 March 2018

Kristi Rothermund

3

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18 March 2018

Lixia Pu

4

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18 March 2018

Simon Watkins

5

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18 March 2018

Fenghua Yi

6

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18 March 2018

Edward V Prochownik

7

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18 March 2018

language of work or name

English

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publication date

1 November 2005

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18 March 2018

published in

Oncogene

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18 March 2018

volume

24

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18 March 2018

issue

51

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18 March 2018

page(s)

7524-7541

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18 March 2018

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

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Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases

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Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

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A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation

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An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.

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AKT plays a central role in tumorigenesis

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Mdm2: A regulator of cell growth and death

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Myc target in myeloid cells-1, a novel c-Myc target, recapitulates multiple c-Myc phenotypes

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The p21(WAF1/CIP1) promoter is methylated in Rat-1 cells: stable restoration of p53-dependent p21(WAF1/CIP1) expression after transfection of a genomic clone containing the p21(WAF1/CIP1) gene

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Phosphorylation of HDM2 by Akt.

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7 January 2021

Regulation of p53 stability

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7 January 2021

Hypophosphorylation of Mdm2 augments p53 stability

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7 January 2021

Translocations involving c-myc and c-myc function

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The CXXC Zn binding motifs of the human papillomavirus type 16 E7 oncoprotein are not required for its in vitro transforming activity in rodent cells.

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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7 January 2021

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

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The INK4a/ARF tumor suppressor: one gene--two products--two pathways

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The CXXC motif: imperatives for the formation of native disulfide bonds in the cell.

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The CXXC motif: a rheostat in the active site.

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7 January 2021

Regulation of p53 stability and activity in response to genotoxic stress.

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7 January 2021

PI 3-kinases and PTEN: how opposites chemoattract

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7 January 2021

A p53-dependent mouse spindle checkpoint

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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7 January 2021

Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo

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7 January 2021

Genomic targets of the human c-Myc protein

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7 January 2021

Identity and functions of CxxC-derived motifs

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7 January 2021

Functions of the MDM2 oncoprotein

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7 January 2021

MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.

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7 January 2021

APOPTOSIS: A Myc-Induced Apoptosis Pathway Surfaces

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Identification and characterization of a family of mammalian methyl-CpG binding proteins

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

c-Myc functionally cooperates with Bax to induce apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Cell death induced by topoisomerase-targeted drugs: more questions than answers

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family

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7 January 2021

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

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7 January 2021

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

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7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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7 January 2021

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

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7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

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7 January 2021

Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis

1 reference

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7 January 2021

Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression

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7 January 2021

BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

MYC oncogenes and human neoplastic disease

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Genetic dissection of c-myc apoptotic pathways

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Kinase phosphorylation: Keeping it all in the family

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Mechanisms of apoptosis by c-Myc

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

1 reference

7 January 2021

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Renewing the debate over the p53 apoptotic response

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Activation of the PI3K/Akt pathway and chemotherapeutic resistance

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Investigation of Aberrant Translational Control of c-myc in Cell Lines Derived from Patients with Multiple Myeloma

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Dynamic in vivo interactions among Myc network members

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Low molecular weight inhibitors of Myc-Max interaction and function

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Novel targets of Akt, p21(Cipl/WAF1), and MDM2.

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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https://api.crossref.org/works/10.1038/SJ.ONC.1208897

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208897

1 reference

18 March 2018

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18 March 2018