Targeted genome modifications using integrase-deficient lentiviral vectors (Q50657873)

17 March 2018

title

Targeted genome modifications using integrase-deficient lentiviral vectors (English)

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17 March 2018

author

Toni Cathomen

series ordinal

2

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17 March 2018

Tatjana I Cornu

series ordinal

1

object named as

Tatjana I Cornu

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17 March 2018

publication date

13 November 2007

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17 March 2018

published in

Molecular Therapy

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17 March 2018

volume

15

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17 March 2018

issue

12

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17 March 2018

page(s)

2107-2113

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17 March 2018

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

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7 January 2021

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

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Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

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Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells

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7 January 2021

Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae

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7 January 2021

Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Gene targeting using zinc finger nucleases

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Human gene targeting by viral vectors

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks

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7 January 2021

Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Hematopoietic stem cell transduction by recombinant adeno-associated virus vectors: problems and solutions

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Retrovirus vectors: toward the plentivirus?

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Gene targeting with retroviral vectors: recombination by gene conversion into regions of nonhomology

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Comparison of wild-type and class I integrase mutant-FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Evidence for gene expression by unintegrated human immunodeficiency virus type 1 DNA species

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Novel integrase-defective lentiviral episomal vectors for gene transfer

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Effective gene therapy with nonintegrating lentiviral vectors

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Use of nonintegrating lentiviral vectors for gene therapy

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Characterization of the minimal DNA-binding domain of the HIV integrase protein

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Acetylation of HIV-1 integrase by p300 regulates viral integration

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Custom zinc-finger nucleases for use in human cells

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Adeno-associated virus vectors integrate at chromosome breakage sites

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Gene targeting with viral vectors

1 reference

https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Gene targeting in mouse embryonic stem cells with an adenoviral vector

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Functions of the adenovirus E4 proteins and their impact on viral vectors

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

High-fidelity correction of mutations at multiple chromosomal positions by adeno-associated virus vectors.

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Gene targeting in vivo by adeno-associated virus vectors.

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors.

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Transient gene expression by nonintegrating lentiviral vectors

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

A third-generation lentivirus vector with a conditional packaging system

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

1 reference

https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

1 reference

https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Chimeric nucleases stimulate gene targeting in human cells

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

An improved zinc-finger nuclease architecture for highly specific genome editing

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay

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https://api.crossref.org/works/10.1038/SJ.MT.6300345

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300345

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17 March 2018

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17 March 2018