Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a (Q50576290)

15 March 2018

title

Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a (English)

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15 March 2018

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4

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author name string

Joshua D Blazek

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1

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15 March 2018

Irushi Abeysekera

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2

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Jiliang Li

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3

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15 March 2018

publication date

23 July 2015

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15 March 2018

published in

Human Molecular Genetics

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volume

24

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issue

20

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page(s)

5687-5696

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Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

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The challenge of Down syndrome

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Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model

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Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice

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Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice.

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A mouse model for Down syndrome exhibits learning and behaviour deficits

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Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis

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Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

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Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

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Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic "Down syndrome" mice

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Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome

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Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

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New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome

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Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A.

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Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity.

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Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction

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DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome

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Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner

21 January 2018

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Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

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Function and regulation of Dyrk1A: towards understanding Down syndrome

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Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice

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Akt Induces Osteoclast Differentiation through Regulating the GSK3β/NFATc1 Signaling Cascade

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Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc

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Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorptive Activity

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Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.

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Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells

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Epigallocatechin-3-gallate inhibits IGF-I-stimulated lung cancer angiogenesis through downregulation of HIF-1α and VEGF expression

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Polyphenols suppress hydrogen peroxide-induced oxidative stress in human bone-marrow derived mesenchymal stem cells

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Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation

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Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn.

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Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

21 January 2018

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Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

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A new mathematical model for relative quantification in real-time RT-PCR

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P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair

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Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype

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Basic biomechanical measurements of bone: a tutorial

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDV284

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15 March 2018

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15 March 2018