Transcriptional Regulation of T Cell Metabolism Reprograming (Q50217785)

27 February 2018

title

Transcriptional Regulation of T Cell Metabolism Reprograming (English)

1 reference

27 February 2018

author name string

Jinxia Zhang

1

1 reference

27 February 2018

Guoyu Bi

2

1 reference

27 February 2018

Yu Xia

3

1 reference

27 February 2018

Pingfei Li

4

1 reference

27 February 2018

Xiaofei Deng

5

1 reference

27 February 2018

Zhengping Wei

6

1 reference

27 February 2018

Xiang-Ping Yang

7

1 reference

27 February 2018

language of work or name

English

0 references

publication date

1 January 2017

1 reference

27 February 2018

Advances in Experimental Medicine and Biology

published in

1 reference

27 February 2018

volume

1011

1 reference

27 February 2018

page(s)

131-152

1 reference

27 February 2018

Differentiation of effector CD4 T cell populations (*)

cites work

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Immunological memory and protective immunity: understanding their relation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Memory CD4 T cells emerge from effector T-cell progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Peripheral CD4 T-cell differentiation regulated by networks of cytokines and transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Effector and memory CTL differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Transcriptional control of effector and memory CD8 T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Diversity in T cell memory: an embarrassment of riches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Heterogeneity and cell-fate decisions in effector and memory CD8 T cell differentiation during viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Synchronizing transcriptional control of T cell metabolism and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Transcriptional regulation of T cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Metabolism in T cell activation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Metabolic pathways in immune cell activation and quiescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Fueling immunity: insights into metabolism and lymphocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Fatty acid metabolism in the regulation of T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

On the Origin of Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Metabolic regulation of T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

How TCRs bind MHCs, peptides, and coreceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

T cell antigen receptor recognition of antigen-presenting molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Serine-threonine kinases in TCR signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Early T cell activation: integrating biochemical, structural, and biophysical cues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

T Cell Fate at the Single-Cell Level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

mTOR, metabolism, and the regulation of T-cell differentiation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

mTORC2 is the hydrophobic motif kinase for SGK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Dominant role of antigen dose in CD4 Foxp3 regulatory T cell induction and expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Duration of antigen receptor signaling determines T-cell tolerance or activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Hypoxia-inducible factors enhance the effector responses of CD8( ) T cells to persistent antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Anergic T cells are metabolically anergic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

New insights into the regulation of T cells by gamma(c) family cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Either IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonobese diabetic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Interleukin 2 plays a central role in Th2 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Interleukin-2 is essential for CD4 CD25 regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Bcl-6 directly represses the gene program of the glycolysis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

IL-7 is essential for homeostatic control of T cell metabolism in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Mitochondrial respiratory capacity is a critical regulator of CD8 T cell memory development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Memory CD8( ) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8 T Cell Longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

IL-15 Promotes the Survival of Naive and Memory Phenotype CD8 T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Inflammatory IL-15 is required for optimal memory T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

MYC on the path to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Global mapping of c-Myc binding sites and target gene networks in human B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Transcriptional amplification in tumor cells with elevated c-Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Proteolytic Control of the Oncoprotein Transcription Factor Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

HIF transcription factors, inflammation, and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Metabolic checkpoints in activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

IRF family of transcription factors as regulators of host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

IRF4 at the crossroads of effector T-cell fate decision

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Interferon regulatory factor 4 sustains CD8( ) T cell expansion and effector differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

BATF-JUN is critical for IRF4-mediated transcription in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

A validated regulatory network for Th17 cell specification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8 T-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Graded levels of IRF4 regulate CD8 T cell differentiation and expansion, but not attrition, in response to acute virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The BTB-ZF Family of Transcription Factors: Key Regulators of Lineage Commitment and Effector Function Development in the Immune System

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Inhibiting glycolytic metabolism enhances CD8 T cell memory and antitumor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Molecular regulation of effector and memory T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Potentiating the antitumour response of CD8( ) T cells by modulating cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Forkhead transcription factors in immunology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Cutting Edge: Foxp1 Controls Naive CD8 T Cell Quiescence by Simultaneously Repressing Key Pathways in Cellular Metabolism and Cell Cycle Progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4 T lymphocytes by CD4 CD25 regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Selective inhibition of CD4 T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Mechanistic target of rapamycin inhibitors in solid organ transplantation: from benchside to clinical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8 T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-94-024-1170-6_3

10.1007/978-94-024-1170-6_3

21 January 2018

Identifiers

DOI

1 reference

27 February 2018

1 reference

27 February 2018