inducible T cell costimulator (Q5009806)

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mammalian protein found in Homo sapiens

• inducible costimulator
• activation-inducible lymphocyte immunomediatory molecule
• inducible T-cell costimulator
• inducible T-cell co-stimulator
• ICOS
• Inducible T-Cell Co-Stimulator Protein

edit

Language	Label	Description	Also known as
English	inducible T cell costimulator	mammalian protein found in Homo sapiens	inducible costimulator activation-inducible lymphocyte immunomediatory molecule inducible T-cell costimulator inducible T-cell co-stimulator ICOS Inducible T-Cell Co-Stimulator Protein

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9Y6W8

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9Y6W8

encoded by

ICOS

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9Y6W8

molecular function

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

determination method or standard

TAS

1 reference

retrieved

7 November 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6W8&geneProductId=UniProtKB:Q9Y6W8

determination method or standard

TAS

protein binding

determination method or standard

IPI

4 references

retrieved

9 May 2019

stated in

A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IPI

retrieved

9 May 2019

stated in

ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IPI

retrieved

9 May 2019

stated in

Ligand binding sites of inducible costimulator and high avidity mutants with improved function

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IPI

retrieved

9 May 2019

stated in

Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IPI

cell component

integral component of membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9Y6W8

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

extracellular region

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9Y6W8

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

plasma membrane

determination method or standard

TAS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9Y6W8

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

integral component of plasma membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9Y6W8

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

external side of plasma membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

biological process

T cell tolerance induction

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

T cell costimulation

determination method or standard

TAS

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

immune response

determination method or standard

NAS

1 reference

retrieved

9 May 2019

stated in

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

GOA

curator

UniProt

UniProt protein ID

Q9Y6W8

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

NAS

phosphatidylinositol phosphate biosynthetic process

determination method or standard

IEA

1 reference

retrieved

7 November 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6W8&geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

cell-cell adhesion

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

positive regulation of protein kinase B signaling

determination method or standard

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

TAS

T cell tolerance induction

determination method or standard

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IBA

T cell costimulation

determination method or standard

IBA

IEA

TAS

4 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IBA

cell-cell adhesion

determination method or standard

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6W8

determination method or standard

IBA

Gene Atlas image

PBB GE ICOS 210439 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q9Y6W8

1 reference

stated in

Identifiers.org

Identifiers

MeSH descriptor ID

D060889

subject named as

Inducible T-Cell Co-Stimulator Protein

0 references

MeSH tree code

D12.776.543.750.705.222.812

0 references

D23.050.301.264.894.580

0 references

D23.101.100.894.580

0 references

RefSeq protein ID

NP_036224

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

29851

UniProt protein ID

Q9Y6W8

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9Y6W8

Ensembl protein ID

ENSP00000319476

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000319476

ENSP00000415951

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000415951

UMLS CUI

C3203085

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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