C-C motif chemokine ligand 20 (Q5009615)

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mammalian protein found in Homo sapiens

• CC chemokine LARC
• small inducible cytokine subfamily A (Cys-Cys), member 20
• small-inducible cytokine A20
• liver and activation-regulated chemokine
• beta chemokine exodus-1
• Beta-chemokine exodus-1
• CCL20
• macrophage inflammatory protein 3 alpha
• chemokine (C-C motif) ligand 20
• MIP-3-alpha
• C-C motif chemokine 20

edit

Language	Label	Description	Also known as
English	C-C motif chemokine ligand 20	mammalian protein found in Homo sapiens	CC chemokine LARC small inducible cytokine subfamily A (Cys-Cys), member 20 small-inducible cytokine A20 liver and activation-regulated chemokine beta chemokine exodus-1 Beta-chemokine exodus-1 CCL20 macrophage inflammatory protein 3 alpha chemokine (C-C motif) ligand 20 MIP-3-alpha C-C motif chemokine 20

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P78556

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P78556

encoded by

CCL20

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P78556

molecular function

cytokine activity

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

protein binding

determination method or standard

IPI

3 references

retrieved

8 April 2019

stated in

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IPI

retrieved

8 April 2019

stated in

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IPI

retrieved

8 April 2019

stated in

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IPI

CCR6 chemokine receptor binding

determination method or standard

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

retrieved

8 April 2019

stated in

Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IDA

retrieved

8 April 2019

stated in

Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IDA

chemokine activity

determination method or standard

IBA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

CCR chemokine receptor binding

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

cell component

extracellular region

determination method or standard

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

intracellular anatomical structure

determination method or standard

IEA

1 reference

retrieved

10 September 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78556&geneProductId=UniProtKB:P78556

determination method or standard

IEA

extracellular space

determination method or standard

IBA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

biological process

monocyte chemotaxis

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

positive regulation of T cell migration

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IDA

neutrophil chemotaxis

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

positive regulation of ERK1 and ERK2 cascade

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

positive regulation of GTPase activity

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

positive regulation of nitric-oxide synthase biosynthetic process

determination method or standard

IEA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78556&geneProductId=UniProtKB:P78556

determination method or standard

IEA

defense response to bacterium

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

cell-cell signaling

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

lymphocyte chemotaxis

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

wound healing

determination method or standard

IEA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78556&geneProductId=UniProtKB:P78556

determination method or standard

IEA

cellular response to lipoteichoic acid

determination method or standard

IEA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78556&geneProductId=UniProtKB:P78556

determination method or standard

IEA

cellular response to tumor necrosis factor

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

cellular response to organic substance

determination method or standard

IEA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78556&geneProductId=UniProtKB:P78556

determination method or standard

IEA

chemokine-mediated signaling pathway

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

cellular response to interleukin-1

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

cellular response to interferon-gamma

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

signal transduction

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

immune response

determination method or standard

IEA

TAS

2 references

retrieved

8 April 2019

stated in

Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

cellular response to lipopolysaccharide

determination method or standard

IEA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78556&geneProductId=UniProtKB:P78556

determination method or standard

IEA

chemotaxis

determination method or standard

IEA

IDA

TAS

4 references

retrieved

8 April 2019

stated in

Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

retrieved

8 April 2019

stated in

Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IDA

calcium-mediated signaling using intracellular calcium source

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IDA

cell chemotaxis

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IDA

T cell migration

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

thymocyte migration

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

inflammatory response

determination method or standard

IBA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Cloning and characterization of exodus, a novel beta-chemokine

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method or standard

IDA

2 references

retrieved

31 January 2018

stated in

Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections.

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78556&geneProductId=UniProtKB:P78556

determination method or standard

IDA

retrieved

31 January 2018

stated in

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.

GOA

curator

UniProt

UniProt protein ID

P78556

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P78556&geneProductId=UniProtKB:P78556

determination method or standard

IDA

regulation of signaling receptor activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IEA

G protein-coupled receptor signaling pathway

determination method or standard

IBA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

IBA

cytokine-mediated signaling pathway

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78556

determination method or standard

TAS

Gene Atlas image

PBB GE CCL20 205476 at fs.png
732 × 530; 10 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P78556

1 reference

stated in

Identifiers.org

Identifiers

MeSH descriptor ID

D054418

subject named as

Chemokine CCL20

0 references

MeSH tree code

D12.644.276.374.200.110.880

0 references

D12.644.276.374.200.600.880

0 references

D12.776.467.374.200.110.880

0 references

D12.776.467.374.200.600.880

0 references

D23.125.300.110.880

0 references

D23.125.300.600.880

0 references

D23.469.200.110.880

0 references

D23.469.200.600.880

0 references

D23.529.374.200.110.880

0 references

D23.529.374.200.600.880

0 references

RefSeq protein ID

NP_001123518

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6364

NP_004582

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6364

UniProt protein ID

P78556

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P78556

Ensembl protein ID

ENSP00000386273

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386273

ENSP00000351671

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000351671

ENSP00000496658

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000496658

Freebase ID

/m/0274qhj

0 references

Microsoft Academic ID

83360876

0 references

OpenAlex ID

C83360876

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

2JYO

1 reference

stated in

UniProt

UniProt protein ID

P78556

retrieved

9 August 2016

language of work or name

English

1M8A

1 reference

stated in

UniProt

UniProt protein ID

P78556

retrieved

9 August 2016

language of work or name

English

2HCI

1 reference

stated in

UniProt

UniProt protein ID

P78556

retrieved

9 August 2016

language of work or name

English

UMLS CUI

C1961104

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(7 entries)

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• cywiki CCL20
• dewiki CCL20
• enwiki CCL20
• shwiki CCL20
• srwiki CCL20
• ttwiki CCL20
• ukwiki CCL20

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q5009615&oldid=2022906514"