Challenges and discoveries in the total synthesis of complex polyketide natural products (Q50079025)

24 February 2018

title

Challenges and discoveries in the total synthesis of complex polyketide natural products (English)

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24 February 2018

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Ian Paterson

1

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24 February 2018

Nelson Yuen Sum Lam

series ordinal

2

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24 February 2018

publication date

25 October 2017

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24 February 2018

The Journal of Antibiotics

published in

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24 February 2018

volume

71

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issue

2

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24 February 2018

page(s)

215-233

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24 February 2018

Marine natural products and related compounds in clinical and advanced preclinical trials

cites work

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Natural Products as Sources of New Drugs from 1981 to 2014.

21 January 2018

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Advances in the total synthesis of biologically important marine macrolides

21 January 2018

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Chemistry. The renaissance of natural products as drug candidates

21 January 2018

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The impact of the Mukaiyama aldol reaction in total synthesis

21 January 2018

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Spirastrellolide A, An Antimitotic Macrolide Isolated from the Caribbean Marine Sponge Spirastrella coccinea

21 January 2018

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Synthesis and stereochemical determination of the spirastrellolides

21 January 2018

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The therapeutic potential of phosphatase inhibitors

21 January 2018

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A total synthesis of spirastrellolide A methyl ester.

21 January 2018

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A general model for selectivity in olefin cross metathesis

21 January 2018

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Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds

21 January 2018

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Catalytic Asymmetric Dihydroxylation

21 January 2018

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Selective grignard-type carbonyl addition of alkenyl halides mediated by chromium(II) chloride

21 January 2018

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Catalytic effect of nickel(II) chloride and palladium(II) acetate on chromium(II)-mediated coupling reaction of iodo olefins with aldehydes

21 January 2018

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An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: a powerful and convenient mixed anhydride method promoted by basic catalysts

21 January 2018

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Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge Leiodermatium sp

21 January 2018

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Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide.

21 January 2018

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Pyridine-derived triflating reagents: An improved preparation of vinyl triflates from metallo enolates

21 January 2018

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Practical methylation of aryl halides by Suzuki–Miyaura coupling

21 January 2018

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Samarium-catalyzed intramolecular Tishchenko reduction of .beta.-hydroxy ketones. A stereoselective approach to the synthesis of differentiated anti 1,3-diol monoesters

21 January 2018

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Directed reduction of .beta.-hydroxy ketones employing tetramethylammonium triacetoxyborohydride

21 January 2018

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Total synthesis of the antimitotic marine macrolide (-)-leiodermatolide

21 January 2018

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New cross-aldol reactions. Reactions of silyl enol ethers with carbonyl compounds activated by titanium tetrachloride

21 January 2018

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Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity.

21 January 2018

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Effects of rhizopodin and latrunculin B on the morphology and on the actin cytoskeleton of mammalian cells

21 January 2018

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Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin

21 January 2018

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Modular total synthesis of rhizopodin: a highly potent G-actin dimerizing macrolide

21 January 2018

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Total synthesis of (-)-reidispongiolide A, an actin-targeting macrolide isolated from the marine sponge Reidispongia coerulea.

21 January 2018

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Catalytic asymmetric epoxidation and kinetic resolution: modified procedures including in situ derivatization

21 January 2018

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Thermal reactions of alkyl N-carbomethoxysulfamate esters

21 January 2018

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Chivosazoles A and F, cytostatic macrolides from myxobacteria, interfere with actin

21 January 2018

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Actin-binding marine macrolides: total synthesis and biological importance

21 January 2018

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An Expedient Total Synthesis of Chivosazole F: an Actin-Binding Antimitotic Macrolide from the Myxobacterium Sorangium Cellulosum.

21 January 2018

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Synthesis of the C1-C13 tetraenoate subunit of the chivosazoles

21 January 2018

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Highly Selective Synthesis of Z -Unsaturated Esters by Using New Horner−Emmons Reagents, Ethyl (Diarylphosphono)acetates

21 January 2018

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Direct synthesis of Z-unsaturated esters. A useful modification of the horner-emmons olefination

21 January 2018

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Spirastrellolide A: revised structure, progress toward the relative configuration, and inhibition of protein phosphatase 2A

21 January 2018

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7 January 2021

Spirastrellolide B reveals the absolute configuration of the spirastrellolide macrolide core

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7 January 2021

Spirastrellolides C to G: macrolides obtained from the marine sponge Spirastrella coccinea

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7 January 2021

Total synthesis of spirastrellolide F methyl ester--part 1: Strategic considerations and revised approach to the southern hemisphere

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7 January 2021

Total synthesis of spirastrellolide F methyl ester--part 2: Macrocyclization and completion of the synthesis

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7 January 2021

Second‐Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route

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7 January 2021

Total synthesis of spirastrellolide A methyl ester--part 1: Synthesis of an advanced C17-C40 bis-spiroacetal subunit

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7 January 2021

Total synthesis of spirastrellolide A methyl ester--part 2: Subunit union and completion of the synthesis

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7 January 2021

A second-generation total synthesis of spirastrellolide A methyl ester

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7 January 2021

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments

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7 January 2021

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis

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7 January 2021

Metathesis reactions in total synthesis

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7 January 2021

Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy

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7 January 2021

Toward the synthesis of spirastrellolide a: construction of a tetracyclic C26-C40 subunit containing the DEF-bis-spiroacetal

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7 January 2021

Diastereo- and Enantioselective Synthesis of syn-alpha-Vinylchlorohydrins and cis-Vinylepoxides

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7 January 2021

Toward the synthesis of spirastrellolide A: construction of two C1-C25 diastereomers containing the BC-spiroacetal

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7 January 2021

The B-Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis A list of abbreviations can be found at the end of the article

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7 January 2021

Assigning stereochemistry to single diastereoisomers by GIAO NMR calculation: the DP4 probability

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7 January 2021

Toward Leiodermatolide: Synthesis of the Core Structure

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7 January 2021

An Approach to the Core Structure of Leiodermatolide

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7 January 2021

Divergent total synthesis of the antimitotic agent leiodermatolide

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7 January 2021

Synthesis of the Macrocyclic Core of Leiodermatolide

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7 January 2021

A versatile protocol for Stille-Migita cross coupling reactions

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7 January 2021

Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties.

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7 January 2021

Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria)

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7 January 2021

Configurational assignment of rhizopodin, an actin-binding macrolide from the myxobacterium Myxococcus stipitatus

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7 January 2021

Stereoselective synthesis of the monomeric unit of actin binding macrolide rhizopodin

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7 January 2021

Synthesis of the C9-C23 (C9'-C23') fragment of the dimeric natural product rhizopodin

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7 January 2021

Formal synthesis of actin binding macrolide rhizopodin

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7 January 2021

Synthesis of the C1-C18 fragment of rhizopodin: late-state introduction of the oxazole

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7 January 2021

Total synthesis of rhizopodin

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7 January 2021

Total synthesis of (-)-rhizopodin

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7 January 2021

Stereocontrolled total synthesis of (-)-callipeltoside A

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7 January 2021

Synthesis of the C(1')--C(11') segment of leucascandrolide A

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7 January 2021

Chivosazol A, a New Inhibitor of Eukaryotic Organisms Isolated from Myxobacteria

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7 January 2021

Antibiotics from Gliding Bacteria, LXXX. Chivosazoles A–F: Novel Antifungal and Cytotoxic Macrolides fromSorangium cellulosum (myxobacteria)

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7 January 2021

Chivosazole A--elucidation of the absolute and relative configuration

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7 January 2021

Total Synthesis of Chivosazole F

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7 January 2021

Aldol reactions in polypropionate synthesis: High π-face selectivity of enol borinates from α-chiral methyl and ethyl ketones under substrate control

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7 January 2021

Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor

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7 January 2021

Synthesis of the C15-C35 northern hemisphere subunit of the chivosazoles

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7 January 2021

Remote asymmetric induction with vinylketene silyl n,o-acetal

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7 January 2021

Pd/P(t-Bu)(3): a mild and general catalyst for Stille reactions of aryl chlorides and aryl bromides

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7 January 2021

Total synthesis of ( )-discodermolide: an improved endgame exploiting a Still-Gennari-type olefination with a C1-C8 beta-ketophosphonate fragment

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7 January 2021

Synthesis of polyketide natural products and analogs as promising anticancer agents

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PubMed

https://pubmed.ncbi.nlm.nih.gov/29066790

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/JA.2017.111

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24 February 2018

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24 February 2018