Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity (Q50024580)

http://europepmc.org/abstract/PMC/5834689

28 June 2018

title

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity (English)

1 reference

http://europepmc.org/abstract/PMC/5834689

28 June 2018

0 references

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

Michael H. Kershaw

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

author name string

A J Davenport

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

R S Cross

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

K A Watson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

Y Liao

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

W Shi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

H M Prince

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

P A Beavis

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

J A Trapani

8

1 reference

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3 June 2020

D S Ritchie

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

P K Darcy

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

M R Jenkins

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

0 references

publication date

12 February 2018

1 reference

http://europepmc.org/abstract/PMC/5834689

28 June 2018

published in

Proceedings of the National Academy of Sciences of the United States of America

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

volume

115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

issue

9

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3 June 2020

page(s)

E2068-E2076

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

3 June 2020

copyright license

start time

12 February 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/5834689

based on heuristic

inferred from PubMed Central ID database lookup

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Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

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Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

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A signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cells

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30 June 2018

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30 June 2018

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30 June 2018

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The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse

30 June 2018

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Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8 T cell-mediated tumor eradication

30 June 2018

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30 June 2018

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An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes

30 June 2018

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Protein kinase C delta localizes to secretory lysosomes in CD8 CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicity

30 June 2018

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LFA-1-mediated T cell costimulation through increased localization of TCR/class II complexes to the central supramolecular activation cluster and exclusion of CD45 from the immunological synapse

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

30 June 2018

1 reference

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Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes

30 June 2018

1 reference

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Bcl-2 overexpression enhances tumor-specific T-cell survival

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

The immunological synapse.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

Three-dimensional segregation of supramolecular activation clusters in T cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

Centrosome polarization delivers secretory granules to the immunological synapse.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

T cell killing does not require the formation of a stable mature immunological synapse.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5834689

14 August 2018

Identifiers

DOI

10.1073/PNAS.1716266115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29440406 AND SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

29440406

1 reference