Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling (Q49850608)

22 February 2018

title

Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling (English)

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22 February 2018

non-alcoholic steatohepatitis

main subject

steatohepatitis

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1 reference

Cynthia Lebeaupin

1

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Carmelo Luci

Carmelo Luci

8

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Philippe Gual

Philippe Gual

15

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Guido Kroemer

12

Guido Kroemer

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22 February 2018

Frédéric Luciano

7

Frederic Luciano

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22 February 2018

author name string

Déborah Vallée

2

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22 February 2018

Déborah Rousseau

3

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22 February 2018

Stéphanie Patouraux

4

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22 February 2018

Stéphanie Bonnafous

5

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22 February 2018

Gilbert Adam

6

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22 February 2018

Rodolphe Anty

9

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22 February 2018

Antonio Iannelli

10

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22 February 2018

Sandrine Marchetti

11

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22 February 2018

Sandra Lacas-Gervais

13

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22 February 2018

Albert Tran

14

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22 February 2018

Béatrice Bailly-Maitre

16

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22 February 2018

language of work or name

English

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publication date

19 February 2018

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22 February 2018

published in

Hepatology

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22 February 2018

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

cites work

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Nonalcoholic fatty liver disease

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Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

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Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

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Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis

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7 January 2021

Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis

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7 January 2021

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

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Decoding cell death signals in liver inflammation

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7 January 2021

Endoplasmic reticulum stress in liver disease

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7 January 2021

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

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7 January 2021

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.

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7 January 2021

ER stress induces NLRP3 inflammasome activation and hepatocyte death.

1 reference

7 January 2021

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

1 reference

7 January 2021

Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance

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7 January 2021

Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury

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7 January 2021

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

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7 January 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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7 January 2021

Getting RIDD of RNA: IRE1 in cell fate regulation

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7 January 2021

Regulation of hepatic lipogenesis by the transcription factor XBP1

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7 January 2021

Osteopontin deficiency aggravates hepatic injury induced by ischemia-reperfusion in mice

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7 January 2021

Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha

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7 January 2021

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

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7 January 2021

Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis

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7 January 2021

Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis

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7 January 2021

Roles of CHOP/GADD153 in endoplasmic reticulum stress

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7 January 2021

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

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7 January 2021

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

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7 January 2021

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

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Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.

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7 January 2021

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

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7 January 2021

Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP).

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7 January 2021

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

1 reference

7 January 2021

BI-1 regulates endoplasmic reticulum Ca2 homeostasis downstream of Bcl-2 family proteins

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7 January 2021

Mice Lacking bi-1 Gene Show Accelerated Liver Regeneration

1 reference

7 January 2021

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

1 reference

7 January 2021

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.

1 reference

7 January 2021

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

1 reference

7 January 2021

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

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7 January 2021

Identifiers

DOI

10.1002/HEP.29847

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22 February 2018

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22 February 2018