Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study (Q49598865)

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scientific article published on 29 January 2018

Language	Label	Description	Also known as
English	Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study	scientific article published on 29 January 2018

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

urinary tract infection

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

acute pyelonephritis

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Lynn E Connolly

1

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

Valerie Riddle

2

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

Deborah Cebrik

3

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

Eliana S Armstrong

4

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

Loren G Miller

5

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

language of work or name

0 references

publication date

29 January 2018

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

Carbapenem resistance, inappropriate empiric treatment and outcomes among patients hospitalized with Enterobacteriaceae urinary tract infection, pneumonia and sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5913993

8 September 2018

Plazomicin Activity against 346 Extended-Spectrum-β-Lactamase/AmpC-Producing Escherichia coli Urinary Isolates in Relation to Aminoglycoside-Modifying Enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5913993

8 September 2018

An update on the management of urinary tract infections in the era of antimicrobial resistance

1 reference

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8 September 2018

Potential economic burden of carbapenem-resistant Enterobacteriaceae (CRE) in the United States.

1 reference

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8 September 2018

Fluoroquinolone-Resistant and Extended-Spectrum β-Lactamase-Producing Escherichia coli Infections in Patients with Pyelonephritis, United States(1).

1 reference

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8 September 2018

Vital Signs: Preventing Antibiotic-Resistant Infections in Hospitals - United States, 2014.

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8 September 2018

Ceftazidime-avibactam Versus Doripenem for the Treatment of Complicated Urinary Tract Infections, Including Acute Pyelonephritis: RECAPTURE, a Phase 3 Randomized Trial Program

1 reference

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8 September 2018

Susceptibility patterns and ESBL rates of Escherichia coli from urinary tract infections in Canada and the United States, SMART 2010-2014.

1 reference

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8 September 2018

Association between the Presence of Aminoglycoside-Modifying Enzymes and In Vitro Activity of Gentamicin, Tobramycin, Amikacin, and Plazomicin against Klebsiella pneumoniae Carbapenemase- and Extended-Spectrum-β-Lactamase-Producing Enterobacter Spec

1 reference

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8 September 2018

Ciprofloxacin resistance in community- and hospital-acquired Escherichia coli urinary tract infections: a systematic review and meta-analysis of observational studies

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Epidemiology of Carbapenem-Resistant Enterobacteriaceae in 7 US Communities, 2012-2013.

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The emerging threat of multidrug-resistant Gram-negative bacteria in urology.

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8 September 2018

Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI).

1 reference

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8 September 2018

Clinical and bacteriological efficacy of amikacin in the treatment of lower urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli or Klebsiella pneumoniae

1 reference

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8 September 2018

Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents.

1 reference

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8 September 2018

Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury

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8 September 2018

In vitro activity of plazomicin against 5,015 gram-negative and gram-positive clinical isolates obtained from patients in canadian hospitals as part of the CANWARD study, 2011-2012.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5913993

8 September 2018

Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden

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8 September 2018

Impact of extended-spectrum β-lactamase-producing organisms on clinical and economic outcomes in patients with urinary tract infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5913993

8 September 2018

Healthcare-associated urinary tract infections in hospitalized urological patients--a global perspective: results from the GPIU studies 2003-2010.

1 reference

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8 September 2018

Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5913993

8 September 2018

Resistance patterns of nosocomial urinary tract infections in urology departments: 8-year results of the global prevalence of infections in urology study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5913993

8 September 2018

Community-associated extended-spectrum β-lactamase-producing Escherichia coli infection in the United States

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5913993

8 September 2018

Predictors of mortality in patients with infections due to multi-drug resistant Gram negative bacteria: the study, the patient, the bug or the drug?

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8 September 2018

Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece

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8 September 2018

Fluoroquinolone resistance among gram-negative urinary tract pathogens: global smart program results, 2009-2010

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8 September 2018

Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin

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8 September 2018

Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects

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8 September 2018

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

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8 September 2018

Current use of aminoglycosides: indications, pharmacokinetics and monitoring for toxicity

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8 September 2018

Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates

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8 September 2018

Complicated urinary tract infections: practical solutions for the treatment of multiresistant Gram-negative bacteria

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Antimicrobial susceptibility of Enterobacteriaceae, including molecular characterization of extended-spectrum beta-lactamase-producing species, in urinary tract isolates from hospitalized patients in North America and Europe: results from the SMART

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12 December 2020

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Identifiers

10.1128/AAC.01989-17

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 February 2018

http://europepmc.org/abstract/MED/29378708

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