Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7. (Q49236261)

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8 April 2020

title

Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7 (English)

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8

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Marta Switalska

9

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Joanna Wietrzyk

10

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Giovanni Luca Beretta

11

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Paola Perego

12

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Maciej Bagiński

14

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1

Majus Misiak

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2

Mateusz Heldt

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6

Grzegorz J Grabe

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Marcin Serocki

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author name string

Marlena Szeligowska

3

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Stefania Mazzini

4

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Leonardo Scaglioni

5

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Dominik Zietkowski

13

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Edward Borowski

15

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Andrzej Skladanowski

16

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language of work or name

English

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publication date

10 October 2017

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volume

8

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issue

62

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8 April 2020

page(s)

105137-105154

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Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks.

8 April 2020

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BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.

22 May 2018

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Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

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The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells

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Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel

22 May 2018

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22 May 2018

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Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

22 May 2018

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The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)(2), d(CGATCG)(2) and d(CGCGCG)(2) shows a strong but reversible binding to G:C base pairs

22 May 2018

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Identification of the molecular basis of doxorubicin-induced cardiotoxicity

22 May 2018

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Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.

22 May 2018

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Fiji: an open-source platform for biological-image analysis

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Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity

22 May 2018

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Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy

22 May 2018

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Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide

22 May 2018

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FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.

22 May 2018

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22 May 2018

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22 May 2018

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Coordination of dual incision and repair synthesis in human nucleotide excision repair

22 May 2018

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Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation

22 May 2018

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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

22 May 2018

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DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

22 May 2018

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NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.

22 May 2018

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Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase

22 May 2018

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DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair.

22 May 2018

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Depletion of topoisomerase IIalpha leads to shortening of the metaphase interkinetochore distance and abnormal persistence of PICH-coated anaphase threads.

22 May 2018

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Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

22 May 2018

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Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

22 May 2018

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Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.

22 May 2018

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Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome

22 May 2018

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Synthesis and DNA binding properties of novel benzo[b]isoquino[2,3-h]-naphthyridines.

22 May 2018

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The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties

22 May 2018

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Microfilament actin remodeling as a potential target for cancer drug development

22 May 2018

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Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer

22 May 2018

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Mode of binding of camptothecins to double helix oligonucleotides

22 May 2018

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Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

22 May 2018

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Requirement of the MRN complex for ATM activation by DNA damage

22 May 2018

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Synthesis and biological evaluation of 2,7-Dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione derivatives, a novel group of anticancer agents active on a multidrug resistant cell line

22 May 2018

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Mode of binding of the cytotoxic alkaloid berberine with the double helix oligonucleotide d(AAGAATTCTT)(2).

22 May 2018

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Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions

22 May 2018

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TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.

22 May 2018

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XK469, a selective topoisomerase IIbeta poison

22 May 2018

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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

22 May 2018

1 reference

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Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin

22 May 2018

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Characterization of covalent adriamycin-DNA adducts

22 May 2018

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Monoclonal antibodies to mitotic cells

22 May 2018

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Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin

22 May 2018

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Nemorubicin and doxorubicin bind the G-quadruplex sequences of the human telomeres and of the c-MYC promoter element Pu22.

22 May 2018

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Tolerated doses in zebrafish of cytochalasins and jasplakinolide for comparison with tolerated doses in mice in the evaluation of pre-clinical activity of microfilament-directed agents in tumor model systems in vivo

14 August 2018

1 reference

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QS‐ZYX‐1‐61 induces apoptosis through topoisomerase II in human non‐small‐cell lung cancer A549 cells

14 August 2018

1 reference

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Interaction between double helix DNA fragments and the new antitumor agent sabarubicin, Men10755.

14 August 2018

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Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death.

14 August 2018

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Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA formed from d(TTAGn) (n=3-5).

14 August 2018

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Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

14 August 2018

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12 December 2020

Inhibition of DNA topoisomerase II by imidazoacridinones, new antineoplastic agents with strong activity against solid tumors

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12 December 2020

Intercalation of imidazoacridinones to DNA and its relevance to cytotoxic and antitumor activity

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12 December 2020

Evaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours

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12 December 2020

10.18632/ONCOTARGET.21806

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29285240 AND SRC:MED&resulttype=core&format=json

8 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29285240 AND SRC:MED&resulttype=core&format=json

8 April 2020

PubMed publication ID

29285240

1 reference