Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration (Q49049463)

http://europepmc.org/abstract/PMC/5102114

18 February 2018

title

Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration (English)

1 reference

http://europepmc.org/abstract/PMC/5102114

18 February 2018

author

T. Michael Redmond

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

William W Hauswirth

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Fan Yang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

Hongwei Ma

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

Joshua Belcher

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

Michael R Butler

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

Sanford L Boye

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

Xi-Qin Ding

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

13 September 2016

1 reference

http://europepmc.org/abstract/PMC/5102114

18 February 2018

published in

FASEB Journal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

issue

12

1 reference

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31 May 2020

page(s)

4313-4325

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

31 May 2020

cites work

1 reference

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Decreased thyroid hormone signaling accelerates the reinnervation of the optic tectum following optic nerve crush in adult zebrafish.

22 May 2018

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Thyroid function and age-related macular degeneration: a prospective population-based cohort study--the Rotterdam Study

22 May 2018

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Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression

22 May 2018

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22 May 2018

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Cone specific promoter for use in gene therapy of retinal degenerative diseases.

22 May 2018

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Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration

22 May 2018

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cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function

22 May 2018

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Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study

22 May 2018

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AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis.

22 May 2018

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Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1

22 May 2018

1 reference

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Thyroid hormone determines the start of the sensitive period of imprinting and primes later learning

22 May 2018

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Mechanisms of thyroid hormone action

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

22 May 2018

1 reference

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Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.

22 May 2018

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Thyroid hormone receptor activity in the absence of ligand: physiological and developmental implications.

22 May 2018

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Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency

22 May 2018

1 reference

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Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Early-Onset, Slow Progression of Cone Photoreceptor Dysfunction and Degeneration in CNG Channel Subunit CNGB3 Deficiency

22 May 2018

1 reference

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The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Epigenetic control of expression of the human L- and M- pigment genes

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Molecular aspects of thyroid hormone actions

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Developmental changes of cone opsin expression but not retinal morphology in the hypothyroid Pax8 knockout mouse

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism

22 May 2018

1 reference

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Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling

22 May 2018

1 reference

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A thyroid hormone deiodinase inhibitor can decrease cutaneous cell proliferation in vitro

22 May 2018

1 reference

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A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study

22 May 2018

1 reference

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Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice

22 May 2018

1 reference

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Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits

22 May 2018

1 reference

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The thyroid hormone-inactivating deiodinase functions as a homodimer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Reawakened interest in type III iodothyronine deiodinase in critical illness and injury

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Deiodinases: implications of the local control of thyroid hormone action

22 May 2018

1 reference

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Antioxidants reduce cone cell death in a model of retinitis pigmentosa

22 May 2018

1 reference

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Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

22 May 2018

1 reference

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Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients

22 May 2018

1 reference

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Substitution of Cysteine for Selenocysteine in the Catalytic Center of Type III Iodothyronine Deiodinase Reduces Catalytic Efficiency and Alters Substrate Preference

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.

22 May 2018

1 reference

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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Nrl is required for rod photoreceptor development

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

A thyroid hormone receptor that is required for the development of green cone photoreceptors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme

22 May 2018

1 reference

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Effects of iopanoic acid on thyroid hormone receptor, growth hormone production, and triiodothyronine generation from thyroxine in pituitary GH1 cells

22 May 2018

1 reference

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Experimental intravitreal ketoconazole in DMSO.

22 May 2018

1 reference

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Induction of STAT3-related genes in fast degenerating cone photoreceptors of cpfl1 mice.

22 May 2018

1 reference

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Implication of type 3 deiodinase induction in zebrafish fin regeneration.

14 August 2018

1 reference

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Dimethyl sulphoxide dose-response on rat retinal function.

14 August 2018

1 reference

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Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement.

14 August 2018

1 reference

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Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis

14 August 2018

1 reference

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Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse

14 August 2018

1 reference

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RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5102114

Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27623928

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27623928

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1096/FJ.201600715R

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27623928 AND SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

27623928

1 reference