c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia (Q48987486)

17 February 2018

title

c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia (English)

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17 February 2018

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10

Uwe-Karsten Hanisch

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17 February 2018

author name string

Vicki Waetzig

1

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17 February 2018

Karen Czeloth

2

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17 February 2018

Ute Hidding

3

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17 February 2018

Kirsten Mielke

4

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17 February 2018

Moritz Kanzow

5

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17 February 2018

Stephan Brecht

6

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17 February 2018

Mario Goetz

7

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17 February 2018

Ralph Lucius

8

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Thomas Herdegen

9

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17 February 2018

publication date

1 May 2005

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17 February 2018

published in

Glia

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17 February 2018

volume

50

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issue

3

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17 February 2018

page(s)

235-246

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17 February 2018

The neuropeptide substance P activates p38 mitogen-activated protein kinase resulting in IL-6 expression independently from NF-kappa B.

cites work

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Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/SAPK) Is Required for Lipopolysaccharide Stimulation of Tumor Necrosis Factor Alpha (TNF-α) Translation: Glucocorticoids Inhibit TNF-α Translation by Blocking JNK/SAPK

21 January 2018

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c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8( ) T cell-mediated antiviral immunity.

21 January 2018

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7 January 2021

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

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7 January 2021

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

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7 January 2021

Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNFα

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7 January 2021

Mammalian MAP kinase signalling cascades

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7 January 2021

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

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7 January 2021

Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.

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7 January 2021

Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein

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7 January 2021

Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

1 reference

7 January 2021

c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.

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7 January 2021

c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8( ) T cell activation

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7 January 2021

c-Jun mediates axotomy-induced dopamine neuron death in vivo

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7 January 2021

Serine proteases and brain damage - is there a link?

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7 January 2021

Characterization of ameboid microglia isolated from developing mammalian brain.

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7 January 2021

Selective interaction of JNK protein kinase isoforms with transcription factors

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7 January 2021

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

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7 January 2021

Microglia as a source and target of cytokines

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7 January 2021

The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls

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7 January 2021

The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines

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7 January 2021

AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration

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7 January 2021

The c-Jun N-terminal kinases in cerebral microglia: immunological functions in the brain

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7 January 2021

Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease

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7 January 2021

Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease

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7 January 2021

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

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7 January 2021

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

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7 January 2021

Mast cell tumor necrosis factor alpha production is regulated by MEK kinases

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7 January 2021

Microglia-specific localisation of a novel calcium binding protein, Iba1

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7 January 2021

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

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7 January 2021

Activator protein 1 activation following hypoosmotic stress in HepG2 cells is actin cytoskeleton dependent

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7 January 2021

Hyperosmotically induced accumulation of a phosphorylated p38-like MAPK involved in protoplast volume regulation of plasmolyzed wheat root cells

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7 January 2021

The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells.

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7 January 2021

Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway

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7 January 2021

MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein

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7 January 2021

Fatal shift of signal transduction is an integral part of neuronal differentiation: JNKs realize TNFalpha-mediated apoptosis in neuronlike, but not naive, PC12 cells.

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7 January 2021

Thrombin-induced activation of cultured rodent microglia

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7 January 2021

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

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7 January 2021

Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease

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7 January 2021

NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci

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7 January 2021

Cell swelling activates stress-activated protein kinases, p38 MAP kinase and JNK, in renal epithelial A6 cells

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7 January 2021

The JNK/c-Jun cascade and Alzheimer's disease

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7 January 2021

Genetic models for CNS inflammation

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7 January 2021

The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho.

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7 January 2021

Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells

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7 January 2021

Microglial activation by components of gram-positive and -negative bacteria: distinct and common routes to the induction of ion channels and cytokines.

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7 January 2021

Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia

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7 January 2021

Changes of the trans-activating potential of AP-1 transcription factor during cyclosporin A-induced apoptosis of glioma cells are mediated by phosphorylation and alterations of AP-1 composition

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7 January 2021

Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

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7 January 2021

Signal transduction by MAP kinases in T lymphocytes

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7 January 2021

c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

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7 January 2021

Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

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7 January 2021

MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo

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7 January 2021

COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells

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7 January 2021

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

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7 January 2021

Effects of MEK inhibitor U0126 on meiotic progression in mouse oocytes: microtuble organization, asymmetric division and metaphase II arrest

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7 January 2021

A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death

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7 January 2021

Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration

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7 January 2021

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

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7 January 2021

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

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7 January 2021

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

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7 January 2021

Identifiers

DOI

10.1002/GLIA.20173

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17 February 2018

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17 February 2018