Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation. (Q48912014)

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scientific article published in September 2011

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English	Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.	scientific article published in September 2011

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12 February 2020

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation (English)

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neurodegeneration

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Stephan von Hörsten

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Anca Alexandru

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Wolfgang Jagla

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Sigrid Graubner

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Andreas Becker

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Christoph Bäuscher

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Stephanie Kohlmann

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Reinhard Sedlmeier

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Raik Rönicke

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Klaus G Reymann

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Maike Hartlage-Rübsamen

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Alexander Waniek

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Steffen Rossner

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Stephan Schilling

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Alexander P Osmand

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Hans-Ulrich Demuth

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Kerstin A Raber

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Elisabeth Petrasch-Parwez

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Journal of Neuroscience

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12790-12801

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12 February 2020

The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

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Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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10.1523/JNEUROSCI.1794-11.2011

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