Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics (Q48825635)

15 February 2018

title

Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics (English)

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15 February 2018

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Keitaro Umezawa

1

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15 February 2018

Masafumi Yoshida

2

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15 February 2018

Mako Kamiya

3

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15 February 2018

Tatsuya Yamasoba

4

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15 February 2018

Yasuteru Urano

5

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15 February 2018

publication date

7 November 2016

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15 February 2018

published in

Nature Chemistry

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15 February 2018

volume

9

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15 February 2018

issue

3

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15 February 2018

page(s)

279-286

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15 February 2018

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The importance of glutathione in human disease

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The role of glutathione in cancer.

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Glutathione in cancer biology and therapy

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CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

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In vivo assessment of cancerous tumors using boron doped diamond microelectrode

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Fluorescent and colorimetric probes for detection of thiols

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Cyanine-based fluorescent probe for highly selective detection of glutathione in cell cultures and live mouse tissues

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Tunable heptamethine-azo dye conjugate as an NIR fluorescent probe for the selective detection of mitochondrial glutathione over cysteine and homocysteine.

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A highly sensitive, cell-membrane-permeable fluorescent probe for glutathione

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Combinatorial rosamine library and application to in vivo glutathione probe

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Theoretical and Experimental Investigation of Thermodynamics and Kinetics of Thiol-Michael Addition Reactions: A Case Study of Reversible Fluorescent Probes for Glutathione Imaging in Single Cells.

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Quantitative imaging of glutathione in live cells using a reversible reaction-based ratiometric fluorescent probe

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Rational design of highly sensitive fluorescence probes for protease and glycosidase based on precisely controlled spirocyclization.

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Quantification of the Electrophilic Reactivities of Aldehydes, Imines, and Enones

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Reference scales for the characterization of cationic electrophiles and neutral nucleophiles

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Bright building blocks for chemical biology

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New trends in near-infrared fluorophores for bioimaging

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Silicon-substituted xanthene dyes and their applications in bioimaging

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Evolution of group 14 rhodamines as platforms for near-infrared fluorescence probes utilizing photoinduced electron transfer

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A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins

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A design concept of long-wavelength fluorescent analogs of rhodamine dyes: replacement of oxygen with silicon atom

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A practical guide for estimating rates of heterolysis reactions

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Mitochondrial glutathione, a key survival antioxidant

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Expression of gamma-glutamyltransferase in cancer cells and its significance in drug resistance

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Rapid cancer detection by topically spraying a γ-glutamyltranspeptidase-activated fluorescent probe

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Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer

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Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.

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Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation

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Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.

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Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation

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Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics.

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Real-time imaging of the intracellular glutathione redox potential.

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Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

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Inhibition of oral cancer cell growth by adenovirusMnSOD plus BCNU treatment

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Glutathione metabolism and its implications for health

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7 January 2021

Ratiometric fluorescence imaging of cellular glutathione

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7 January 2021

BODIPY-based ratiometric fluorescent sensor for highly selective detection of glutathione over cysteine and homocysteine

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7 January 2021

Development of a highly specific rhodamine-based fluorescence probe for hypochlorous acid and its application to real-time imaging of phagocytosis

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A spontaneously blinking fluorophore based on intramolecular spirocyclization for live-cell super-resolution imaging.

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Scales of Lewis basicities toward C-centered Lewis acids (carbocations)

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Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

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7 January 2021

Identifiers

DOI

10.1038/NCHEM.2648

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15 February 2018

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15 February 2018