The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy (Q48728744)

15 February 2018

title

The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy (English)

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15 February 2018

author name string

Sven Geisler

1

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15 February 2018

Stefanie Vollmer

2

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Sonia Golombek

3

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Philipp J Kahle

4

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language of work or name

English

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publication date

6 June 2014

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15 February 2018

published in

Journal of Cell Science

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15 February 2018

volume

127

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issue

Pt 15

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page(s)

3280-3293

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15 February 2018

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

cites work

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Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

21 January 2018

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Autoregulation of Parkin activity through its ubiquitin-like domain

21 January 2018

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The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

21 January 2018

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UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients.

21 January 2018

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Alterations in the common fragile site gene Parkin in ovarian and other cancers

21 January 2018

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Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

21 January 2018

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A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling

21 January 2018

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UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

21 January 2018

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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

21 January 2018

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

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The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

21 January 2018

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy

21 January 2018

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Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

21 January 2018

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Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.

21 January 2018

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Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

21 January 2018

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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21 January 2018

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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

21 January 2018

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Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data

21 January 2018

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PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

21 January 2018

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

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Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch

21 January 2018

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UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation

21 January 2018

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

21 January 2018

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p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

21 January 2018

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p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

21 January 2018

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Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase

21 January 2018

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Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

21 January 2018

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

21 January 2018

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Diverse polyubiquitin interaction properties of ubiquitin-associated domains

21 January 2018

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Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

21 January 2018

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Physiological functions of the HECT family of ubiquitin ligases

21 January 2018

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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

21 January 2018

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Novel pharmacological targets for the treatment of Parkinson's disease

21 January 2018

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Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

21 January 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

21 January 2018

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

21 January 2018

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Structure of parkin reveals mechanisms for ubiquitin ligase activation

21 January 2018

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

21 January 2018

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

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Structure of the human Parkin ligase domain in an autoinhibited state

21 January 2018

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UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

21 January 2018

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The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

21 January 2018

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Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

21 January 2018

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Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

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21 January 2018

Identifiers

DOI

10.1242/JCS.146035

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15 February 2018

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15 February 2018