Cystine/glutamate antiporter blockage induces myelin degeneration. (Q48703799)

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3 April 2020

title

Cystine/glutamate antiporter blockage induces myelin degeneration (English)

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8

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Federico N Soria

1

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Olatz Pampliega

3

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Aitor Palomino

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Cristina Miguelez

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Luisa Ugedo

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María Domercq

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author name string

Alazne Zabala

2

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Hideyo Sato

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publication date

1 June 2016

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volume

64

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issue

8

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page(s)

1381-1395

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Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target

3 April 2020

cites work

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CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity

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Distribution of the cystine/glutamate antiporter system xc- in the brain, kidney, and duodenum

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Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols

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The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures

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Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

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Inhibition of cystine uptake disrupts the growth of primary brain tumors

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The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond

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Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility.

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System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes.

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Metabolism and functions of glutathione in brain.

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Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination

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Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression

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Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia

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Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain

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Expression and developmental regulation of the cystine/glutamate exchanger (xc-) in the rat

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Regulation of xCT expression and system x (c) (-) function in neuronal cells.

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The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases

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Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS.

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System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency

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Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission

21 January 2018

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Cerebral cystine uptake: a tale of two transporters

21 January 2018

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System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

21 January 2018

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Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

21 January 2018

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Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking

21 January 2018

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Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Müller glial cells

21 January 2018

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Increased expression of cystine/glutamate antiporter in multiple sclerosis

21 January 2018

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Nuclear factor-kappa B activation in human testicular apoptosis

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Visualising the activity of the cystine-glutamate antiporter in glial cells using antibodies to aminoadipic acid, a selectively transported substrate

21 January 2018

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In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas

21 January 2018

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Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

21 January 2018

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Redox imbalance in cystine/glutamate transporter-deficient mice

21 January 2018

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Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.

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Reactive oxygen species in cancer cells: live by the sword, die by the sword.

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The uptake of cysteine in cultured primary astrocytes and neurons

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Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.

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Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

21 January 2018

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Characterization of L-alpha-aminoadipic acid transport in cultured rat astrocytes

21 January 2018

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Increased expression and function of glutamate transporters in multiple sclerosis

21 January 2018

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

21 January 2018

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Regulation of hippocampal synaptic strength by glial xCT.

21 January 2018

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Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion

21 January 2018

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7 January 2021

The origin and neuronal function of in vivo nonsynaptic glutamate.

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7 January 2021

Purkinje cell survival and axonal regeneration are age dependent: an in vitro study.

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7 January 2021

Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress

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7 January 2021

Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention

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7 January 2021

Glutathione efflux from cultured astrocytes

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7 January 2021

Maintenance of neuronal glutathione by glial cells

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7 January 2021

Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain.

1 reference

7 January 2021

Regulation of the System x−C cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures

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7 January 2021

Astrocytes provide cysteine to neurons by releasing glutathione

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7 January 2021

Cystine deprivation induces oligodendroglial death: rescue by free radical scavengers and by a diffusible glial factor

1 reference

7 January 2021

Identifiers

DOI

10.1002/GLIA.23011

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3 April 2020

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