Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration. (Q48701226)

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20 January 2020

title

Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration (English)

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Markus R Wenk

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20 January 2020

author name string

Jeyapriya R Sundaram

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20 January 2020

Elizabeth S Chan

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20 January 2020

Charlene P Poore

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20 January 2020

Wei Fun Cheong

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Guanghou Shui

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20 January 2020

Ning Tang

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Chian-Ming Low

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Sashi Kesavapany

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language of work or name

English

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publication date

1 January 2012

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20 January 2020

published in

Journal of Neuroscience

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volume

32

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issue

3

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page(s)

1020-1034

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

20 January 2020

cites work

1 reference

12 December 2020

Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord.

1 reference

12 December 2020

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

1 reference

12 December 2020

beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

12 December 2020

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

1 reference

12 December 2020

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

1 reference

12 December 2020

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

1 reference

12 December 2020

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice

1 reference

12 December 2020

Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammali

1 reference

12 December 2020

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

1 reference

12 December 2020

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

1 reference

12 December 2020

AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.

1 reference

12 December 2020

CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.

1 reference

12 December 2020

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

1 reference

12 December 2020

Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.

1 reference

12 December 2020

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

12 December 2020

Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases

1 reference

12 December 2020

Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide

1 reference

12 December 2020

Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

1 reference

12 December 2020

p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in ne

1 reference

12 December 2020

The role of inflammation in Alzheimer's disease

1 reference

12 December 2020

Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-beta peptide

1 reference

12 December 2020

A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

1 reference

12 December 2020

Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation.

1 reference

12 December 2020

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

1 reference

12 December 2020

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

1 reference

12 December 2020

p35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease.

1 reference

12 December 2020

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

12 December 2020

A pathogenic role for CD8 T cells in a spontaneous model of demyelinating disease

1 reference

12 December 2020

Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders

1 reference

12 December 2020

The role of astrocytes in the physiology and pathology of the central nervous system

1 reference

12 December 2020

Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration

1 reference

12 December 2020

p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons

1 reference

12 December 2020

Acyl chain-dependent effect of lysophosphatidylcholine on human neutrophils

1 reference

12 December 2020

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.

1 reference

12 December 2020

Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration

1 reference

12 December 2020

The Cyclin-dependent Kinase Family

1 reference

12 December 2020

Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides.

1 reference

12 December 2020

Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2.

1 reference

12 December 2020

Infiltration of CD4 lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

1 reference

12 December 2020

Lysophosphatidylcholine induces glial cell activation: role of rho kinase

1 reference

12 December 2020

An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease

1 reference

12 December 2020

Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration

1 reference

12 December 2020

Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity

1 reference

12 December 2020

Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay

1 reference

12 December 2020

Myelin lipids in aging human brain.

1 reference

12 December 2020

Significance of plasma lysolecithin in patients with multiple sclerosis: a longitudinal study

1 reference

12 December 2020

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids

1 reference

12 December 2020

Metabolism of very long-chain monounsaturated fatty acids (22:1) and the adaptation to their presence in the diet.

1 reference

12 December 2020

A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains

1 reference

12 December 2020

Tumor necrosis factor alpha and transforming growth factor beta upregulate astrocyte expression of monocyte chemoattractant protein-1

1 reference

12 December 2020

Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.

1 reference

12 December 2020

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

1 reference

12 December 2020

The growing phospholipase A2 superfamily of signal transduction enzymes

1 reference

12 December 2020

Membrane phospholipid alterations in Alzheimer's disease: deficiency of ethanolamine plasmalogens

1 reference

12 December 2020

Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain

1 reference

12 December 2020

Function and inhibition of intracellular calcium-independent phospholipase A2.

1 reference

12 December 2020

10.1523/JNEUROSCI.5177-11.2012

Identifiers

DOI

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20 January 2020

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20 January 2020

PubMed publication ID

22262900

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