Immune monitoring of transplant patients in transient mixed chimerism tolerance trials (Q48510142)

12 February 2018

review article

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title

Immune monitoring of transplant patients in transient mixed chimerism tolerance trials (English)

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12 February 2018

author name string

Megan Sykes

series ordinal

1

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12 February 2018

publication date

28 December 2017

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12 February 2018

published in

Human Immunology

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12 February 2018

Alloimmune T cells in transplantation

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Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells

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HLA-mismatched renal transplantation without maintenance immunosuppression

8 September 2018

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Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine

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The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia

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An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues

8 September 2018

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Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses.

8 September 2018

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Host MHC class II antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions

8 September 2018

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Mechanisms of the antitumor responses and host-versus-graft reactions induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: a critical role for recipient CD4 T cells and recipient leukocyte infusion

8 September 2018

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Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol

8 September 2018

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Tolerance in mixed chimerism - a role for regulatory cells?

8 September 2018

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Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells

8 September 2018

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Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation

8 September 2018

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Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L.

8 September 2018

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Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma

8 September 2018

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Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies

8 September 2018

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8 September 2018

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Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease

8 September 2018

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Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation.

8 September 2018

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Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death

8 September 2018

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Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies

8 September 2018

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Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance

8 September 2018

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Multiple levels of peripheral tolerance

8 September 2018

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Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells

8 September 2018

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Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen

8 September 2018

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Early regulation of CD8 T cell alloreactivity by CD4 CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8 T cells, precluding a role for sustained regulation

8 September 2018

1 reference

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Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

2 November 2018

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Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5924718

Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys

2 November 2018

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12 December 2020

Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen

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12 December 2020

Effect of natural killer cell depletion on long-term multilineage allogeneic bone marrow engraftment

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12 December 2020

Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation

1 reference

12 December 2020

Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body

1 reference

12 December 2020

Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance

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12 December 2020

Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose

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12 December 2020

Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation

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12 December 2020

Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen

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12 December 2020

Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

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12 December 2020

Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses

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12 December 2020

A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT

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12 December 2020

CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway

1 reference

12 December 2020

Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance

1 reference

12 December 2020

Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance

1 reference

12 December 2020

Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys

1 reference

12 December 2020

Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4 cells

1 reference

12 December 2020

Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells

1 reference

12 December 2020

Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant

1 reference

12 December 2020

Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplan

1 reference

12 December 2020

Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism

1 reference

12 December 2020

Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning

1 reference

12 December 2020

Earlier low-dose TBI or DST overcomes CD8 T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L

1 reference

12 December 2020

CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates

1 reference

12 December 2020

Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation

1 reference

12 December 2020

Quantitating effector and regulatory T lymphocytes in immune responses by limiting dilution analysis modeling

1 reference

12 December 2020

Role of indirect allo- and autoreactivity in anti-tumor responses induced by recipient leukocyte infusions (RLI) in mixed chimeras prepared with nonmyeloablative conditioning

1 reference

12 December 2020

Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR

1 reference

12 December 2020

Clinical relevance of recipient leukocyte infusion as antitumor therapy following nonmyeloablative allogeneic hematopoietic cell transplantation

1 reference

12 December 2020

Cutting Edge: Intrathymic Differentiation of Adaptive Foxp3 Regulatory T Cells upon Peripheral Proinflammatory Immunization

1 reference

12 December 2020

HLA-mismatched renal transplantation without maintenance immunosuppression

1 reference

12 December 2020

10.1016/J.HUMIMM.2017.12.011

Identifiers

DOI

1 reference

12 February 2018

PMC publication ID

5924718

0 references

1 reference

12 February 2018