Domain analysis of Ras-association domain family member 6 upon interaction with MDM2. (Q48371919)

11 February 2018

title

Domain analysis of Ras-association domain family member 6 upon interaction with MDM2. (English)

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11 February 2018

author name string

Aradhan Sarkar

1

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11 February 2018

Hiroaki Iwasa

2

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11 February 2018

Shakhawoat Hossain

3

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11 February 2018

Xiaoyin Xu

4

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11 February 2018

Takeru Sawada

5

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11 February 2018

Takanobu Shimizu

6

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11 February 2018

Junichi Maruyama

7

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11 February 2018

Kyoko Arimoto-Matsuzaki

8

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11 February 2018

Yutaka Hata

9

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11 February 2018

language of work or name

English

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publication date

5 January 2017

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11 February 2018

published in

FEBS Letters

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11 February 2018

volume

591

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11 February 2018

issue

2

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11 February 2018

page(s)

260-272

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11 February 2018

RASSF6; the Putative Tumor Suppressor of the RASSF Family

cites work

1 reference

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The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias

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The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma

21 January 2018

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RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells

21 January 2018

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Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma.

21 January 2018

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Decreased expression of RASSF6 is a novel independent prognostic marker of a worse outcome in gastric cancer patients after curative surgery

21 January 2018

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Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival

21 January 2018

1 reference

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The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1873-3468.12551

Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways

21 January 2018

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Hippo pathway-dependent and -independent roles of RASSF6.

21 January 2018

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RASSF6 is a novel member of the RASSF family of tumor suppressors

21 January 2018

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A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

21 January 2018

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MDM2, MDMX and p53 in oncogenesis and cancer therapy

21 January 2018

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The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death

21 January 2018

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The RASSF1A tumor suppressor activates Bax via MOAP-1.

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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MDM2 oligomers: antagonizers of the guardian of the genome

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo

21 January 2018

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The central region of HDM2 provides a second binding site for p53.

21 January 2018

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The C terminus of p53 binds the N-terminal domain of MDM2.

21 January 2018

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Identification of a novel Ras-regulated proapoptotic pathway

21 January 2018

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https://api.crossref.org/works/10.1002/1873-3468.12551

NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.

21 January 2018

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https://api.crossref.org/works/10.1002/1873-3468.12551

21 January 2018

Identifiers

DOI

10.1002/1873-3468.12551

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11 February 2018

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11 February 2018