Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease. (Q48314660)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186562 AND SRC:MED&resulttype=core&format=json

2 April 2020

title

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186562 AND SRC:MED&resulttype=core&format=json

2 April 2020

0 references

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P Hemachandra Reddy

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186562 AND SRC:MED&resulttype=core&format=json

2 April 2020

publication date

1 April 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186562 AND SRC:MED&resulttype=core&format=json

2 April 2020

published in

Human Molecular Genetics

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2 April 2020

volume

26

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2 April 2020

issue

8

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2 April 2020

page(s)

1483-1496

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Intracellular amyloid-beta in Alzheimer's disease

2 April 2020

cites work

1 reference

Pathways towards and away from Alzheimer's disease

21 January 2018

1 reference

Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline

21 January 2018

1 reference

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics

21 January 2018

1 reference

Oxidative damage in Alzheimer's

21 January 2018

1 reference

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

21 January 2018

1 reference

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

21 January 2018

1 reference

Structural correlates of cognition in dementia: quantification and assessment of synapse change.

21 January 2018

1 reference

Mitochondria-Targeted Antioxidant SS31 Prevents Amyloid Beta-Induced Mitochondrial Abnormalities and Synaptic Degeneration in Alzheimer's Disease

21 January 2018

1 reference

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

21 January 2018

1 reference

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.

21 January 2018

1 reference

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease

21 January 2018

1 reference

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

21 January 2018

1 reference

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

21 January 2018

1 reference

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

21 January 2018

1 reference

Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease

21 January 2018

1 reference

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

21 January 2018

1 reference

Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage

21 January 2018

1 reference

Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease

21 January 2018

1 reference

Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

21 January 2018

1 reference

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

21 January 2018

1 reference

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

21 January 2018

1 reference

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

21 January 2018

1 reference

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

21 January 2018

1 reference

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

21 January 2018

1 reference

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

21 January 2018

1 reference

Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows

21 January 2018

1 reference

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

21 January 2018

1 reference

Mitochondria-targeted peptide antioxidants: novel neuroprotective agents

21 January 2018

1 reference

Targeting antioxidants to mitochondria: a new therapeutic direction

21 January 2018

1 reference

Synthesis and in vitro opioid activity profiles of DALDA analogues

21 January 2018

1 reference

Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury

21 January 2018

1 reference

Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function

21 January 2018

1 reference

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

21 January 2018

1 reference

Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

21 January 2018

1 reference

Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay

21 January 2018

1 reference

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

21 January 2018

1 reference

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

21 January 2018

1 reference

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

21 January 2018

1 reference

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

21 January 2018

1 reference

Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease

21 January 2018

1 reference

Oxidative damage as an early marker of Alzheimer's disease and mild cognitive impairment.

21 January 2018

1 reference

Involvement of oxidative stress in Alzheimer disease

21 January 2018

1 reference

Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass

21 January 2018

1 reference

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease

21 January 2018

1 reference

Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Elevation of glutathione as a therapeutic strategy in Alzheimer disease

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Pathogenesis of Alzheimer's disease

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Mitochondrial abnormalities in Alzheimer's disease.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Alzheimer's disease: genes, proteins, and therapy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075532

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

2 November 2018

1 reference

Potent mitochondria-targeted peptides reduce myocardial infarction in rats

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28186562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28186562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDX052

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186562 AND SRC:MED&resulttype=core&format=json

2 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186562 AND SRC:MED&resulttype=core&format=json

2 April 2020

PubMed publication ID

28186562

1 reference