GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. (Q48096449)

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1 March 2020

title

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1 (English)

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12

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Berthold Gottgens

14

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Georges Lacaud

16

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Victoria Moignard

4

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Elli Marinopoulou

6

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Christophe Lancrin

8

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Shaun M Cowley

13

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10

Tarik Möröy

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11

Catherine Robin

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author name string

Roshana Thambyrajah

1

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Milena Mazan

2

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Rahima Patel

3

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Monika Stefanska

5

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Yaoyong Li

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Thomas Clapes

9

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Valerie Kouskoff

15

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publication date

30 November 2015

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number of pages

12

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inferred from page(s)

published in

Nature Cell Biology

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volume

18

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issue

1

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page(s)

21-32

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Origin of blood cells and HSC production in the embryo.

1 March 2020

cites work

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Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo

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Continuous single-cell imaging of blood generation from haemogenic endothelium.

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The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

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Haematopoietic stem cells derive directly from aortic endothelium during development

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Blood stem cells emerge from aortic endothelium by a novel type of cell transition.

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Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells.

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Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

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Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta

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Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta

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The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis

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Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro

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Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo

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Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

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GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

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Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region

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Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin CD45 pre-definitive HSCs

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Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos

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Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development

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Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1

21 January 2018

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The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

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Blood cell generation from the hemangioblast.

21 January 2018

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Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability

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The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

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Detection of in vivo protein-DNA interactions using DamID in mammalian cells

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RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence.

21 January 2018

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RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

21 January 2018

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Regulation of vascular permeability by sphingosine 1-phosphate

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A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development

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Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

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The Notch pathway in the developing hematopoietic system

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Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

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SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development

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The expression of Sox17 identifies and regulates haemogenic endothelium

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Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta.

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Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

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Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells

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Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation

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In vivo repopulating activity emerges at the onset of hematopoietic specification during embryonic stem cell differentiation.

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Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches.

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Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression

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HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

21 January 2018

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Induction of a hemogenic program in mouse fibroblasts

21 January 2018

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Reprogramming human endothelial cells to haematopoietic cells requires vascular induction

21 January 2018

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Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells

21 January 2018

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Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.

21 January 2018

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Smooth muscle cells largely develop independently of functional hemogenic endothelium.

21 January 2018

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Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development

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Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis

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Definitive hematopoiesis is autonomously initiated by the AGM region

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12 December 2020

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

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12 December 2020

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity

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12 December 2020

Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver

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12 December 2020

Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny.

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12 December 2020

Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.

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12 December 2020

Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells

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12 December 2020

Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.

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12 December 2020

Identifiers

DOI

10.1038/NCB3276

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1 March 2020

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