Toxicogenomics: The challenges and opportunities to identify biomarkers, signatures and thresholds to support mode-of-action (Q47985821)

7 February 2018

title

Toxicogenomics: the challenges and opportunities to identify biomarkers, signatures and thresholds to support mode-of-action (English)

1 reference

7 February 2018

Toxicogenomics: The challenges and opportunities to identify biomarkers, signatures and thresholds to support mode-of-action (English)

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

28 December 2024

1 reference

1 reference

1

Richard A. Currie

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22448638

28 December 2024

language of work or name

English

0 references

publication date

13 March 2012

1 reference

7 February 2018

full work available at URL

https://api.elsevier.com/content/article/PII:S1383571812000691?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

https://api.elsevier.com/content/article/PII:S1383571812000691?httpAccept=text/plain

28 December 2024

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

28 December 2024

1 reference

7 February 2018

volume

746

1 reference

7 February 2018

issue

2

1 reference

7 February 2018

page(s)

97-103

1 reference

7 February 2018

Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach

cites work

1 reference

5 May 2024

https://opencitations.net/index/api/v1/citations/10.1021/PR0703021

Identification of toxicologically predictive gene sets using cDNA microarrays

1

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Application of genomic biomarkers to predict increased lung tumor incidence in 2-year rodent cancer bioassays

28 December 2024

2

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver

28 December 2024

3

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

28 December 2024

4

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity

28 December 2024

5

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals

28 December 2024

6

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Predictive toxicogenomics approaches reveal underlying molecular mechanisms of nongenotoxic carcinogenicity

28 December 2024

7

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Toxicogenomics in risk assessment: an overview of an HESI collaborative research program

28 December 2024

8

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

28 December 2024

9

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Reproducibility of microarray data: a further analysis of microarray quality control (MAQC) data

28 December 2024

10

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

28 December 2024

11

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

28 December 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Transcriptional profiles in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: Propiconazole, triadimefon, and myclobutanil.

28 December 2024

14

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

28 December 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

28 December 2024

16

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

A framework for human relevance analysis of information on carcinogenic modes of action

28 December 2024

17

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

IPCS framework for analyzing the relevance of a cancer mode of action for humans.

28 December 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

The Key Events Dose-Response Framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds

28 December 2024

20

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Application of key events analysis to chemical carcinogens and noncarcinogens

28 December 2024

21

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

An integrated functional genomic study of acute phenobarbital exposure in the rat

28 December 2024

22

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure

28 December 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens

28 December 2024

24

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment

28 December 2024

25

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

28 December 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling

28 December 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Quantification of information transfer via cellular signal transduction pathways

28 December 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Untangling the wires: a strategy to trace functional interactions in signaling and gene networks

28 December 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Network motifs: simple building blocks of complex networks

28 December 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Formation of regulatory patterns during signal propagation in a Mammalian cellular network

28 December 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

From components to regulatory motifs in signalling networks

28 December 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia

28 December 2024

34

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Gadd45 family proteins are coactivators of nuclear hormone receptors

28 December 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription

28 December 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B

28 December 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

28 December 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition

28 December 2024

39

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.

28 December 2024

40

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate

28 December 2024

41

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors

28 December 2024

42

1 reference

https://api.crossref.org/works/10.1016/J.MRGENTOX.2012.03.002

28 December 2024

Identifiers

1 reference

7 February 2018

1 reference

7 February 2018