Intracellular iron and heme trafficking and metabolism in developing erythroblasts (Q47969812)

7 February 2018

title

Intracellular iron and heme trafficking and metabolism in developing erythroblasts (English)

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7 February 2018

author name string

Martin D Kafina

series ordinal

1

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7 February 2018

Barry H Paw

series ordinal

2

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7 February 2018

publication date

10 August 2017

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7 February 2018

published in

Metallomics

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7 February 2018

volume

9

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7 February 2018

issue

9

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7 February 2018

page(s)

1193-1203

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7 February 2018

Iron and porphyrin trafficking in heme biogenesis

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Iron transport proteins: Gateways of cellular and systemic iron homeostasis

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Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro

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Intracellular iron transport and storage: from molecular mechanisms to health implications

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Iron-sulfur cluster biogenesis and trafficking in mitochondria

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Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways

21 January 2018

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Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

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Cellular and mitochondrial iron homeostasis in vertebrates

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Iron homeostasis: An anthropocentric perspective

21 January 2018

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Molecular liaisons between erythropoiesis and iron metabolism

21 January 2018

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Hepcidin in the diagnosis of iron disorders

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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

21 January 2018

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A Red Carpet for Iron Metabolism.

21 January 2018

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Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

21 January 2018

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

21 January 2018

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Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

21 January 2018

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Snx3 regulates recycling of the transferrin receptor and iron assimilation

21 January 2018

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A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice

21 January 2018

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Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin.

21 January 2018

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A cytosolic iron chaperone that delivers iron to ferritin.

21 January 2018

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PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

21 January 2018

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Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2.

21 January 2018

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Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase

21 January 2018

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Special delivery: distributing iron in the cytosol of mammalian cells

21 January 2018

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Cytosolic iron chaperones: Proteins delivering iron cofactors in the cytosol of mammalian cells

21 January 2018

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Coming into view: eukaryotic iron chaperones and intracellular iron delivery

21 January 2018

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Erythroid cell mitochondria receive endosomal iron by a "kiss-and-run" mechanism.

21 January 2018

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Mitoferrin is essential for erythroid iron assimilation

21 January 2018

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Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria.

21 January 2018

1 reference

Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria

21 January 2018

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Molecular mechanisms of iron uptake in fungi

21 January 2018

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Iron uptake in fungi: a system for every source

21 January 2018

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Fungal physiology: Robbing the bank of haem iron

21 January 2018

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Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2

21 January 2018

1 reference

Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.

21 January 2018

1 reference

Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis

21 January 2018

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Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis

21 January 2018

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ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation

21 January 2018

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The GATA factor revolution in hematology

21 January 2018

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GATA factor mutations in hematologic disease

21 January 2018

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Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies

21 January 2018

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Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

21 January 2018

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The ferritin Fe2 site at the diiron catalytic center controls the reaction with O2 in the rapid mineralization pathway.

21 January 2018

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A human mitochondrial ferritin encoded by an intronless gene

21 January 2018

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Identification of a human heme exporter that is essential for erythropoiesis

21 January 2018

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A heme export protein is required for red blood cell differentiation and iron homeostasis

21 January 2018

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The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

21 January 2018

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The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation

21 January 2018

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Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin

21 January 2018

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Do Mammalian Cells Really Need to Export and Import Heme?

21 January 2018

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Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

21 January 2018

1 reference

Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia

21 January 2018

1 reference

The role of iron in mitochondrial function

21 January 2018

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Mitochondrial transport of protoporphyrinogen IX in erythroid cells

21 January 2018

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Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia

21 January 2018

1 reference

Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia

21 January 2018

1 reference

Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia.

21 January 2018

1 reference

Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome

21 January 2018

1 reference

Structure and function of enzymes in heme biosynthesis.

21 January 2018

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Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis.

21 January 2018

1 reference

p16INK4a induces an age-dependent decline in islet regenerative potential

21 January 2018

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ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis

21 January 2018

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One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans

21 January 2018

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Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.

21 January 2018

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TMEM14C is required for erythroid mitochondrial heme metabolism

21 January 2018

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Heme and erythropoieis: more than a structural role.

21 January 2018

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Coordinate expression of heme and globin is essential for effective erythropoiesis

21 January 2018

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Mammalian iron metabolism and its control by iron regulatory proteins

21 January 2018

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The role of iron regulatory proteins in mammalian iron homeostasis and disease

21 January 2018

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Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis

21 January 2018

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Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation

21 January 2018

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Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

21 January 2018

1 reference

The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload.

21 January 2018

1 reference

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

21 January 2018

1 reference

Human high-altitude adaptation: forward genetics meets the HIF pathway.

21 January 2018

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The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption

21 January 2018

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Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

21 January 2018

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

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Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

21 January 2018

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Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

21 January 2018

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The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

21 January 2018

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Hypoxia-inducible factors link iron homeostasis and erythropoiesis

21 January 2018

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Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis

21 January 2018

1 reference

AAA proteins: have engine, will work

21 January 2018

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ClpXP, an ATP-powered unfolding and protein-degradation machine

21 January 2018

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Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

21 January 2018

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Lack of heme synthesis in a free-living eukaryote

21 January 2018

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Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

21 January 2018

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HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis

21 January 2018

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Control of metazoan heme homeostasis by a conserved multidrug resistance protein

21 January 2018

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Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel

21 January 2018

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Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.

21 January 2018

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The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase

21 January 2018

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C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload

21 January 2018

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Erythroid heme biosynthesis and its disorders

21 January 2018

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Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5607108

5-aminolevulinate synthase: catalysis of the first step of heme biosynthesis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5607108

Identification of a mammalian mitochondrial porphyrin transporter

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5607108

Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5607108

Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5607108

When Is a Heme Transporter Not a Heme Transporter? When It's a Folate Transporter

2 November 2018

1 reference

12 December 2020

The aconitase function of iron regulatory protein 1. Genetic studies in yeast implicate its role in iron-mediated redox regulation

1 reference

12 December 2020

Direct interorganellar transfer of iron from endosome to mitochondrion

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12 December 2020

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12 December 2020

X-linked protoporphyria: Iron supplementation improves protoporphyrin overload, liver damage and anaemia

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12 December 2020

Identifiers

DOI

10.1039/C7MT00103G

1 reference

7 February 2018

PMC publication ID

5607108

0 references

1 reference

7 February 2018