Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling (Q47933697)

6 February 2018

review article

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title

Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling (English)

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6 February 2018

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Abraham RT

1

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6 February 2018

publication date

1 June 1998

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6 February 2018

Current Opinion in Immunology

published in

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6 February 2018

volume

10

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6 February 2018

issue

3

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6 February 2018

page(s)

330-336

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6 February 2018

Immunopharmacology of rapamycin

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

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TOR2 is required for organization of the actin cytoskeleton in yeast

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When is a lipid kinase not a lipid kinase? When it is a protein kinase

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Phosphoinositide kinases

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Cell-cycle signaling: Atm displays its many talents

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atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

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7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

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The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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7 January 2021

Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells

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7 January 2021

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

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7 January 2021

A signaling pathway to translational control

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7 January 2021

Initiation of protein synthesis in eukaryotic cells

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7 January 2021

Translational controls impinging on the 5'-untranslated region and initiation factor proteins

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7 January 2021

Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E

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Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

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Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

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7 January 2021

Ras mediates translation initiation factor 4E-induced malignant transformation

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7 January 2021

Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

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7 January 2021

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells

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7 January 2021

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

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7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

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7 January 2021

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

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7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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7 January 2021

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

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7 January 2021

Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes

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7 January 2021

Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells

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7 January 2021

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

1 reference

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7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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7 January 2021

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating

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7 January 2021

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

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7 January 2021

10.1016/S0952-7915(98)80172-6

Identifiers

DOI

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6 February 2018

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6 February 2018