CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects. (Q47924309)

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17 March 2020

title

CSP-1103 (CHF5074) stabilizes human transthyretin in healthy human subjects (English)

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human subject research project

17 March 2020

main subject

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author

Bruno Imbimbo

9

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17 March 2020

author name string

Lixia Qiang

1

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17 March 2020

Yanxia Guan

2

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17 March 2020

Xiangshun Li

3

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17 March 2020

Li Liu

4

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17 March 2020

Yanshuang Mu

5

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17 March 2020

Aki Sugano

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17 March 2020

Yutaka Takaoka

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17 March 2020

Toshiyuki Sakaeda

8

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17 March 2020

Ken-Ichi Yamamura

10

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17 March 2020

Shoude Jin

11

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17 March 2020

Zhenghua Li

12

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17 March 2020

publication date

1 March 2017

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17 March 2020

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17 March 2020

volume

24

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17 March 2020

issue

1

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17 March 2020

page(s)

42-51

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The evolution of transthyretin synthesis in the choroid plexus

17 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Characterization of a major development-regulated serum thyroxine-binding globulin in the euthyroid mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Rational design of potent human transthyretin amyloid disease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Inhibiting transthyretin amyloid fibril formation via protein stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Structural evidence for native state stabilization of a conformationally labile amyloidogenic transthyretin variant by fibrillogenesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Pharmacokinetics and pharmacodynamics of CHF5074 after short-term administration in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

The biological and chemical basis for tissue-selective amyloid disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Binding and stabilization of transthyretin by curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Inhibition of transthyretin amyloid fibril formation by 2,4-dinitrophenol through tetramer stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

The chemistry, pharmacology and clinical pharmacology of diflunisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Risk of cardiovascular events associated with selective COX-2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

The long-term impact of liver transplantation on kidney function in familial amyloidotic polyneuropathy patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Variation in amount of wild-type transthyretin in different fibril and tissue types in ATTR amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

A different amyloid formation mechanism: de novo oculoleptomeningeal amyloid deposits after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Liver Transplantation Does Not Prevent the Development of Life-Threatening Arrhythmia in Familial Amyloidotic Polyneuropathy, Portuguese-Type (ATTR Val30Met) Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Liver Transplantation for Familial Amyloidotic Polyneuropathy (FAP): A Single-Center Experience Over 16 Years

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Gastric emptying before and after liver transplantation for familial amyloidotic polyneuropathy, Portuguese type (Val30Met)

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1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

Progression of cardiac amyloid deposition in hereditary transthyretin amyloidosis patients after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/13506129.2017.1308348

10.1080/13506129.2017.1308348

21 January 2018

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28393633 AND SRC:MED&resulttype=core&format=json

17 March 2020

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