Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. (Q47887304)

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scientific article published on 2 January 2018

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English	Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2.	scientific article published on 2 January 2018

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scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29292987 AND SRC:MED&resulttype=core&format=json

8 April 2020

Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2 (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29292987 AND SRC:MED&resulttype=core&format=json

8 April 2020

Jianxiong Jiang

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29292987 AND SRC:MED&resulttype=core&format=json

8 April 2020

Raymond Dingledine

4

1 reference

Europe PubMed Central

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8 April 2020

3

object named as

Thota Ganesh

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Europe PubMed Central

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8 April 2020

author name string

Tri Minh Van

2

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Europe PubMed Central

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8 April 2020

publication date

4 January 2018

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8 April 2020

ACS Chemical Neuroscience

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8 April 2020

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29292987 AND SRC:MED&resulttype=core&format=json

8 April 2020

4

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Europe PubMed Central

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8 April 2020

699-707

1 reference

Europe PubMed Central

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8 April 2020

COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles of PGE2 receptors in models of neurological disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling via the prostaglandin E₂ receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of G protein-coupled receptors by allosteric ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EP2 receptor signaling pathways regulate classical activation of microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of allosteric modulators of GPCRs for treatment of CNS disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by vascular prostaglandin E2 signaling in hypoxic-ischemic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EP2 Receptor Signaling Regulates Microglia Death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 EP2 receptor deletion attenuates intracerebral hemorrhage-induced brain injury and improves functional recovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 in glioblastoma multiforme

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of EP2 receptor suppresses poly(I: C) and LPS-mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for MAPKs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29292987

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACSCHEMNEURO.7B00486

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29292987 AND SRC:MED&resulttype=core&format=json

8 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29292987 AND SRC:MED&resulttype=core&format=json

8 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29292987 AND SRC:MED&resulttype=core&format=json

8 April 2020

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