Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease (Q47884196)

6 February 2018

title

Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease (English)

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6 February 2018

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M Hasan Mohajeri

1

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6 February 2018

Katrin Kuehnle

2

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6 February 2018

Hong Li

3

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6 February 2018

Raphael Poirier

4

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6 February 2018

Jay Tracy

5

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6 February 2018

Roger M Nitsch

6

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6 February 2018

language of work or name

English

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publication date

1 March 2004

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6 February 2018

published in

FEBS Letters

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6 February 2018

volume

562

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6 February 2018

issue

1-3

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6 February 2018

page(s)

16-21

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6 February 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Evidence that Aβ42 is the real culprit in alzheimer's disease

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Translating cell biology into therapeutic advances in Alzheimer's disease

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Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation?

21 January 2018

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Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Metabolic regulation of brain Abeta by neprilysin

21 January 2018

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Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons

21 January 2018

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Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo

21 January 2018

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21 January 2018

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Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging

21 January 2018

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Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition

21 January 2018

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21 January 2018

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A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

21 January 2018

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Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation

21 January 2018

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Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

21 January 2018

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Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

21 January 2018

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

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Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide

21 January 2018

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Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII.

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Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity

21 January 2018

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A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11)

21 January 2018

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

7 January 2021

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

7 January 2021

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10.1016/S0014-5793(04)00169-3

7 January 2021

Identifiers

DOI

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6 February 2018

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6 February 2018