p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis. (Q47860140)

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29 March 2020

title

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis (English)

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10

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Khalil Saadipour

1

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Noralyn B Mañucat-Tan

2

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Yoon Lim

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Damien J Keating

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Larisa Bobrovskaya

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Yan-Jiang Wang

9

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Xin-Fu Zhou

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author name string

Kevin S Smith

5

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Jin-Hua Zhong

6

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Hong Liao

7

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29 March 2020

language of work or name

English

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publication date

27 September 2017

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Journal of Neurochemistry

29 March 2020

number of pages

16

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based on heuristic

inferred from page(s)

published in

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volume

144

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issue

3

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page(s)

302-317

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c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration

29 March 2020

cites work

1 reference

Neurotrophins, synaptic plasticity and dementia

21 January 2018

1 reference

The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development

21 January 2018

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Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family

21 January 2018

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A Dual Mechanism Linking NGF/proNGF Imbalance and Early Inflammation to Alzheimer's Disease Neurodegeneration in the AD11 Anti-NGF Mouse Model

21 January 2018

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

21 January 2018

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Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice

21 January 2018

1 reference

The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease

21 January 2018

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JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

21 January 2018

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Effects of chronic variable stress on cognition and Bace1 expression among wild-type mice

21 January 2018

1 reference

An aging pathway controls the TrkA to p75NTR receptor switch and amyloid beta-peptide generation

21 January 2018

1 reference

BACE1 mRNA Expression in Alzheimer's Disease Postmortem Brain Tissue

21 January 2018

1 reference

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

21 January 2018

1 reference

Neurotrophins Redirect p75NTR from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport

21 January 2018

1 reference

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

21 January 2018

1 reference

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin

21 January 2018

1 reference

Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction

21 January 2018

1 reference

Synaptic and endosomal localization of active gamma-secretase in rat brain

21 January 2018

1 reference

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

1 reference

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth

21 January 2018

1 reference

Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles

21 January 2018

1 reference

The role of proteolysis in Alzheimer's disease

21 January 2018

1 reference

Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms

21 January 2018

1 reference

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

21 January 2018

1 reference

p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17.

21 January 2018

1 reference

Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.

21 January 2018

1 reference

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

1 reference

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo

21 January 2018

1 reference

A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress

21 January 2018

1 reference

Regulation of cell survival by secreted proneurotrophins

21 January 2018

1 reference

APP processing is regulated by cytoplasmic phosphorylation

21 January 2018

1 reference

Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

21 January 2018

1 reference

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.

21 January 2018

1 reference

Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway

21 January 2018

1 reference

Lesion-induced expression of low-affinity nerve growth factor receptor-immunoreactive protein in Purkinje cells of the adult rat.

21 January 2018

1 reference

NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons.

21 January 2018

1 reference

The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.

21 January 2018

1 reference

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

21 January 2018

1 reference

Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease

21 January 2018

1 reference

Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease.

21 January 2018

1 reference

Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice

21 January 2018

1 reference

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

21 January 2018

1 reference

Sortilin is essential for proNGF-induced neuronal cell death

21 January 2018

1 reference

Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease

21 January 2018

1 reference

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

21 January 2018

1 reference

Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway

21 January 2018

1 reference

Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system

21 January 2018

1 reference

The molecular pathology of Alzheimer's disease

21 January 2018

1 reference

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

21 January 2018

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Phosphorylation of beta-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis

21 January 2018

1 reference

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

21 January 2018

1 reference

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

Preparing Synthetic Aβ in Different Aggregation States

21 January 2018

1 reference

ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA.

21 January 2018

1 reference

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid

21 January 2018

1 reference

Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway

21 January 2018

1 reference

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

21 January 2018

1 reference

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

21 January 2018

1 reference

Amyloid precursor protein trafficking, processing, and function

21 January 2018

1 reference

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

21 January 2018

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.

21 January 2018

1 reference

Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice

21 January 2018

1 reference

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

21 January 2018

1 reference

Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling

21 January 2018

1 reference

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

1 reference

Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing

21 January 2018

1 reference

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons

21 January 2018

1 reference

The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking

21 January 2018

1 reference

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease

21 January 2018

1 reference

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains

21 January 2018

1 reference

Roles of p75NTR in the pathogenesis of Alzheimer's disease: a novel therapeutic target

21 January 2018

1 reference

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

21 January 2018

1 reference

Brain-derived neurotrophic factor in neurodegenerative diseases

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.14206

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28869759 AND SRC:MED&resulttype=core&format=json

29 March 2020

1 reference