Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment (Q47851530)

6 February 2018

title

Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment (English)

1 reference

6 February 2018

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cognitive dysfunction

1 reference

Candice E Van Skike

1

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author name string

Jordan B Jahrling

2

1 reference

6 February 2018

Angela B Olson

3

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6 February 2018

Naomi L Sayre

4

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6 February 2018

Stacy A Hussong

5

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6 February 2018

Zoltan I Ungvari

6

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6 February 2018

James D Lechleiter

7

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6 February 2018

Veronica Galvan

8

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6 February 2018

publication date

22 December 2017

1 reference

6 February 2018

American Journal of Physiology Heart and Circulatory Physiology

published in

1 reference

6 February 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5966773/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro

26 August 2018

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Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

26 August 2018

1 reference

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Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

26 August 2018

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26 August 2018

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26 August 2018

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Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

26 August 2018

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Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier

26 August 2018

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Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats

26 August 2018

1 reference

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood-brain barrier dysfunction in vivo

26 August 2018

1 reference

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

26 August 2018

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Significant negative correlations between capillary expressed eNOS and Alzheimer lesion burden

26 August 2018

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

26 August 2018

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Brain endothelial cell-cell junctions: how to "open" the blood brain barrier

26 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

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26 August 2018

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Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease

26 August 2018

1 reference

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A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain

26 August 2018

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Cis-dimerization mediates function of junctional adhesion molecule A.

26 August 2018

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G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences

26 August 2018

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Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease

26 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat.

26 August 2018

1 reference

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Microvascular injury and blood-brain barrier leakage in Alzheimer's disease

26 August 2018

1 reference

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Matrix metalloproteinase-9 is associated with blood-brain barrier opening and brain edema formation after cortical contusion in rats.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

The blood-brain barrier/neurovascular unit in health and disease

26 August 2018

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Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Involvement of the junctional adhesion molecule-1 (JAM1) homodimer interface in regulation of epithelial barrier function.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

A simple method for isolation and characterization of mouse brain microvascular endothelial cells

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Alterations of the blood-brain barrier and glial cells in white-matter lesions in cerebrovascular and Alzheimer's disease patients

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Permeability of blood-brain barrier to various sized molecules

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5966773

Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29351469

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29351469

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1152/AJPHEART.00570.2017

1 reference

6 February 2018

PMC publication ID

5966773

0 references

1 reference

6 February 2018