Tumor suppressor C-RASSF proteins (Q47850088)

6 February 2018

http://europepmc.org/abstract/MED/29353317

title

Tumor suppressor C-RASSF proteins (English)

1 reference

6 February 2018

http://europepmc.org/abstract/MED/29353317

author

Yutaka Hata

series ordinal

3

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6 June 2020

author name string

Hiroaki Iwasa

series ordinal

1

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6 June 2020

Shakhawoat Hossain

series ordinal

2

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6 June 2020

publication date

20 January 2018

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6 February 2018

http://europepmc.org/abstract/MED/29353317

published in

Cellular and Molecular Life Sciences

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6 June 2020

volume

75

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6 June 2020

issue

10

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6 June 2020

page(s)

1773-1787

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Identification of Nore1 as a potential Ras effector

6 June 2020

cites work

1 reference

12 December 2020

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

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12 December 2020

The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function

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12 December 2020

The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1

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12 December 2020

Identification of a novel Ras-regulated proapoptotic pathway

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12 December 2020

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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12 December 2020

RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1

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12 December 2020

The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation

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12 December 2020

NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancers

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12 December 2020

RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor

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12 December 2020

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

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12 December 2020

Control of microtubule stability by the RASSF1A tumor suppressor

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12 December 2020

Haplotype mapping of the bronchiolitis susceptibility locus near IL8.

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12 December 2020

Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene

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12 December 2020

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

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12 December 2020

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death

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12 December 2020

Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

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12 December 2020

Novel functional interaction between the plasma membrane Ca2 pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1).

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12 December 2020

RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics

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12 December 2020

A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability

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12 December 2020

Inactivation of RASSF1C during in vivo tumor growth identifies it as a tumor suppressor gene

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12 December 2020

Aberrant methylation of RASSF4/AD037 in nasopharyngeal carcinoma.

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12 December 2020

The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles

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12 December 2020

RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.

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12 December 2020

Tumor susceptibility of Rassf1a knockout mice

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12 December 2020

Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5

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12 December 2020

Transcriptional regulation of cyclin A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin A2 promoter

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12 December 2020

CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.

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12 December 2020

The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death

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12 December 2020

Involvement of the RASSF1A tumor suppressor gene in controlling cell migration

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12 December 2020

The RASSF1A tumor suppressor activates Bax via MOAP-1.

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12 December 2020

Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

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12 December 2020

NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma

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12 December 2020

GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.

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12 December 2020

Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.

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12 December 2020

Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation

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12 December 2020

Ras association domain family 1C protein stimulates human lung cancer cell proliferation

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12 December 2020

RASSF1A suppresses oncogenic H-Ras-induced c-Jun N-terminal kinase activation.

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12 December 2020

The Drosophila RASSF homolog antagonizes the hippo pathway

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12 December 2020

RASSF1C, an Isoform of the Tumor Suppressor RASSF1A, Promotes the Accumulation of β-Catenin by Interacting with βTrCP

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12 December 2020

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

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12 December 2020

Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways

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12 December 2020

RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.

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12 December 2020

RASSF6 is a novel member of the RASSF family of tumor suppressors

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12 December 2020

Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway

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12 December 2020

Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation

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12 December 2020

The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex

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12 December 2020

RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

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12 December 2020

Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer.

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12 December 2020

Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition

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12 December 2020

RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers

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12 December 2020

The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells

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12 December 2020

Dynamics of RASSF1A/MOAP-1 association with death receptors.

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12 December 2020

The tumour suppressor RASSF1A is a novel substrate of PKC.

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12 December 2020

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex

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12 December 2020

NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis

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12 December 2020

Rassf family of tumor suppressor polypeptides.

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12 December 2020

Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice.

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12 December 2020

RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt.

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12 December 2020

Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity

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12 December 2020

The RASSF proteins in cancer; from epigenetic silencing to functional characterization

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12 December 2020

RASSF2 associates with and stabilizes the proapoptotic kinase MST2

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12 December 2020

Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2.

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12 December 2020

RAN GTPase is a RASSF1A effector involved in controlling microtubule organization.

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12 December 2020

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias

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12 December 2020

Hippo pathway-dependent and -independent roles of RASSF6.

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12 December 2020

Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody.

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12 December 2020

ATM regulates a RASSF1A-dependent DNA damage response

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12 December 2020

Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity

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12 December 2020

The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation

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12 December 2020

14-3-3 mediated regulation of the tumor suppressor protein, RASSF1A.

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12 December 2020

The Ras effector RASSF2 controls the PAR-4 tumor suppressor

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12 December 2020

Protein kinase A-mediated phosphorylation of the RASSF1A tumour suppressor at Serine 203 and regulation of RASSF1A function

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12 December 2020

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling

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12 December 2020

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

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12 December 2020

Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy

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12 December 2020

The Hippo Signaling Pathway in Development and Cancer

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12 December 2020

Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis

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12 December 2020

Deficiency of Rap1-Binding Protein RAPL Causes Lymphoproliferative Disorders through Mislocalization of p27kip1

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12 December 2020

The Tumor Suppressor RASSF1A Prevents Dephosphorylation of the Mammalian STE20-like Kinases MST1 and MST2

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12 December 2020

Microtubule-associated Protein 1S (MAP1S) Bridges Autophagic Components with Microtubules and Mitochondria to Affect Autophagosomal Biogenesis and Degradation

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12 December 2020

Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions

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12 December 2020

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice

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12 December 2020

RASSF1A inhibits estrogen receptor alpha expression and estrogen-independent signalling: implications for breast cancer development.

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12 December 2020

The cellular apoptosis susceptibility CAS/CSE1L gene protects ovarian cancer cells from death by suppressing RASSF1C.

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12 December 2020

A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma

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12 December 2020

Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells

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12 December 2020

RASSF1C modulates the expression of a stem cell renewal gene, PIWIL1.

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12 December 2020

The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53.

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12 December 2020

Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis

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12 December 2020

Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1.

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12 December 2020

C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response

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12 December 2020

Structural and thermodynamic characterization of Nore1-SARAH: a small, helical module important in signal transduction networks

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12 December 2020

Comparative analysis of interactions of RASSF1-10.

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12 December 2020

The E3 ubiquitin ligase Itch regulates tumor suppressor protein RASSF5/NORE1 stability in an acetylation-dependent manner

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12 December 2020

RASSF1A-mediated regulation of AREG via the Hippo pathway in hepatocellular carcinoma.

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12 December 2020

RASSF1A Suppresses Cell Migration through Inactivation of HDAC6 and Increase of Acetylated α-Tubulin

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12 December 2020

Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5

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12 December 2020

The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein.

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12 December 2020

The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury

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12 December 2020

Mitotic arrest by tumor suppressor RASSF1A is regulated via CHK1 phosphorylation

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12 December 2020

RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer

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12 December 2020

The RASSF1 Gene and the Opposing Effects of the RASSF1A and RASSF1C Isoforms on Cell Proliferation and Apoptosis

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12 December 2020

Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression

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12 December 2020

RASSF tumor suppressor gene family: biological functions and regulation

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12 December 2020

RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma

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12 December 2020

RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression

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12 December 2020

lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK.

1 reference

12 December 2020

The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-α signalling in cardiomyocytes.

1 reference

12 December 2020

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

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12 December 2020

Regulation and involvement in cancer and pathological conditions of MAGI1, a tight junction protein

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12 December 2020

Downregulation of Ras association domain family member 6 (RASSF6) underlies the treatment resistance of highly metastatic nasopharyngeal carcinoma cells

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12 December 2020

Architecture of tight junctions and principles of molecular composition

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12 December 2020

Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.

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12 December 2020

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

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12 December 2020

The RASSF1A tumor suppressor regulates XPA-mediated DNA repair

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12 December 2020

MAGI2/S-SCAM outside brain

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12 December 2020

Regulation of mammalian Ste20 (Mst) kinases

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12 December 2020

NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.

1 reference

12 December 2020

Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival

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12 December 2020

Identification of protein arginine N-methyltransferase 5 (PRMT5) as a novel interacting protein with the tumor suppressor protein RASSF1A.

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12 December 2020

RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion

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12 December 2020

Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion

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12 December 2020

Ras Regulates Rb via NORE1A.

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12 December 2020

RASSF6; the Putative Tumor Suppressor of the RASSF Family

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12 December 2020

Mechanisms of Hippo pathway regulation

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12 December 2020

RASSF1A inhibits gastric cancer cell proliferation by miR-711- mediated downregulation of CDK4 expression

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12 December 2020

RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

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12 December 2020

RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis

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12 December 2020

Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1.

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12 December 2020

Proteomics Analysis Reveals Novel RASSF2 Interaction Partners

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12 December 2020

NORE1A Regulates MDM2 Via β-TrCP.

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12 December 2020

Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling

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12 December 2020

H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization

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12 December 2020

TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation

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12 December 2020

Decreased expression of EZH2 reactivates RASSF2A by reversal of promoter methylation in breast cancer cells

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12 December 2020

RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro

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12 December 2020

Cancer-associated fibroblasts promote cancer cell growth through a miR-7-RASSF2-PAR-4 axis in the tumor microenvironment

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12 December 2020

miR-181a-5p promotes the progression of gastric cancer via RASSF6-mediated MAPK signalling activation

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12 December 2020

Domain analysis of Ras-association domain family member 6 upon interaction with MDM2.

1 reference

12 December 2020

RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells

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12 December 2020

MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5.

1 reference

12 December 2020

Rassf Proteins as Modulators of Mst1 Kinase Activity

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12 December 2020

Identification and characterization of RASSF1C piRNA target genes in lung cancer cells

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12 December 2020

RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2.

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12 December 2020

Loss of RASSF4 expression in multiple myeloma promotes RAS-driven malignant progression.

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12 December 2020

10.1007/S00018-018-2756-5

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29353317 AND SRC:MED&resulttype=core&format=json

6 June 2020

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