Keeping an old friend under control: regulation of p53 stability (Q47786180)

5 February 2018

review article

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title

Keeping an old friend under control: regulation of p53 stability (English)

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5 February 2018

author name string

Kubbutat MH

series ordinal

1

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5 February 2018

Vousden KH

series ordinal

2

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5 February 2018

publication date

1 June 1998

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5 February 2018

Trends in Molecular Medicine

published in

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5 February 2018

volume

4

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5 February 2018

issue

6

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5 February 2018

page(s)

250-256

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5 February 2018

p53 in signaling checkpoint arrest or apoptosis

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mdm2 expression is induced by wild type p53 activity

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

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Small peptides activate the latent sequence-specific DNA binding function of p53.

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Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

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p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

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Identifiers

DOI

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5 February 2018

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5 February 2018